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Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients.
Hahn BH, Anderson M, Le E, La Cava A. Hahn BH, et al. Among authors: la cava a. Arthritis Rheum. 2008 Aug;58(8):2488-97. doi: 10.1002/art.23609. Arthritis Rheum. 2008. PMID: 18668553
CONCLUSION: These results suggest a new modality to reverse the functional deficit of Treg cells in SLE patients with positive autoimmune serology, and identify a new strategy to enhance immunoregulatory T cell activity in human SLE....
CONCLUSION: These results suggest a new modality to reverse the functional deficit of Treg cells in SLE patients with positive autoim …
Proinflammatory responses to self HLA epitopes are triggered by molecular mimicry to Epstein-Barr virus proteins in oligoarticular juvenile idiopathic arthritis.
Massa M, Mazzoli F, Pignatti P, De Benedetti F, Passalia M, Viola S, Samodal R, La Cava A, Giannoni F, Ollier W, Martini A, Albani S. Massa M, et al. Among authors: la cava a. Arthritis Rheum. 2002 Oct;46(10):2721-9. doi: 10.1002/art.10564. Arthritis Rheum. 2002. PMID: 12384932
CONCLUSION: Our data suggest a disease- and allele-specific mechanism of autoimmunity in oligoarticular JIA. This mechanism may be part of the pathogenesis of the disease, and could be the basis of one of the likely multiple candidates for antigen-specific immunotherapy ap …
CONCLUSION: Our data suggest a disease- and allele-specific mechanism of autoimmunity in oligoarticular JIA. This mechanism may be pa …
Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis.
Massa M, Costouros N, Mazzoli F, De Benedetti F, La Cava A, Le T, De Kleer I, Ravelli A, Liotta M, Roord S, Berry C, Pachman LM, Martini A, Albani S. Massa M, et al. Among authors: la cava a. Arthritis Rheum. 2002 Nov;46(11):3015-25. doi: 10.1002/art.10566. Arthritis Rheum. 2002. PMID: 12428245
CONCLUSION: These findings represent the first identification of a self epitope in juvenile DM, providing a potential candidate for antigen-specific immune therapy....
CONCLUSION: These findings represent the first identification of a self epitope in juvenile DM, providing a potential candidat …
Leptin-based immune intervention: current status and future directions.
La Cava A, Matarese G, Ebling FM, Hahn BH. La Cava A, et al. Curr Opin Investig Drugs. 2003 Nov;4(11):1327-32. Curr Opin Investig Drugs. 2003. PMID: 14758772 Review.
Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. ...
Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on differen …
Differences between CD8+ T cells in lupus-prone (NZB x NZW) F1 mice and healthy (BALB/c x NZW) F1 mice may influence autoimmunity in the lupus model.
Karpouzas GA, La Cava A, Ebling FM, Singh RR, Hahn BH. Karpouzas GA, et al. Among authors: la cava a. Eur J Immunol. 2004 Sep;34(9):2489-99. doi: 10.1002/eji.200424978. Eur J Immunol. 2004. PMID: 15307181 Free PMC article.
Immunization with portions of a murine antibody to DNA induced Ig peptide-reactive peripheral CD8+ inhibitory T (Ti) cells in non-autoimmune (BALB/c x NZW) F1 (CWF1) mice. ...
Immunization with portions of a murine antibody to DNA induced Ig peptide-reactive peripheral CD8+ inhibitory T (Ti) cells in non-aut …
Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA.
La Cava A, Ebling FM, Hahn BH. La Cava A, et al. J Immunol. 2004 Sep 1;173(5):3542-8. doi: 10.4049/jimmunol.173.5.3542. J Immunol. 2004. PMID: 15322219
Cellular and molecular mechanisms of regulation of autoantibody production in lupus.
Hahn BH, Ebling F, Singh RR, Singh RP, Karpouzas G, La Cava A. Hahn BH, et al. Among authors: la cava a. Ann N Y Acad Sci. 2005 Jun;1051:433-41. doi: 10.1196/annals.1361.085. Ann N Y Acad Sci. 2005. PMID: 16126985 Free PMC article. Review.
Manipulation of immune regulation in systemic lupus erythematosus.
La Cava A, Fang CJ, Singh RP, Ebling F, Hahn BH. La Cava A, et al. Autoimmun Rev. 2005 Nov;4(8):515-9. doi: 10.1016/j.autrev.2005.04.008. Autoimmun Rev. 2005. PMID: 16214088 Review.
Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors.
Hahn BH, Singh RP, La Cava A, Ebling FM. Hahn BH, et al. Among authors: la cava a. J Immunol. 2005 Dec 1;175(11):7728-37. doi: 10.4049/jimmunol.175.11.7728. J Immunol. 2005. PMID: 16301683
CD4+CD25+ Tregs and NKT cells: regulators regulating regulators.
La Cava A, Van Kaer L, Fu-Dong-Shi. La Cava A, et al. Trends Immunol. 2006 Jul;27(7):322-7. doi: 10.1016/j.it.2006.05.003. Epub 2006 Jun 2. Trends Immunol. 2006. PMID: 16735139 Review.
Although most studies have investigated the regulatory properties of these T-cell subsets independently of each other, recent reports have provided evidence for cross-talk between Tregs and NKT cells, and, consequently, the immunoregulatory networks are seen in a new persp …
Although most studies have investigated the regulatory properties of these T-cell subsets independently of each other, recent reports have p …
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