La Gruta NL - Search Results

1

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses.

Wu T, Guan J, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP, Purcell AW, La Gruta NL. Wu T, et al. Among authors: la gruta nl. Nat Commun. 2019 Jun 28;10(1):2846. doi: 10.1038/s41467-019-10661-8. Nat Commun. 2019. PMID: 31253788 Free PMC article.

2

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations.

Turner SJ, Kedzierska K, Komodromou H, La Gruta NL, Dunstone MA, Webb AI, Webby R, Walden H, Xie W, McCluskey J, Purcell AW, Rossjohn J, Doherty PC. Turner SJ, et al. Among authors: la gruta nl. Nat Immunol. 2005 Apr;6(4):382-9. doi: 10.1038/ni1175. Epub 2005 Feb 27. Nat Immunol. 2005. PMID: 15735650

3

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides.

La Gruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ. La Gruta NL, et al. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2034-9. doi: 10.1073/pnas.0711682102. Epub 2008 Jan 31. Proc Natl Acad Sci U S A. 2008. PMID: 18238896 Free PMC article.

4

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses.

Kedzierska K, Thomas PG, Venturi V, Davenport MP, Doherty PC, Turner SJ, La Gruta NL. Kedzierska K, et al. Among authors: la gruta nl. J Immunol. 2008 Aug 15;181(4):2556-62. doi: 10.4049/jimmunol.181.4.2556. J Immunol. 2008. PMID: 18684946 Free PMC article.

5

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

Jenkins MR, La Gruta NL, Doherty PC, Trapani JA, Turner SJ, Waterhouse NJ. Jenkins MR, et al. Among authors: la gruta nl. Cell Death Differ. 2009 Apr;16(4):537-42. doi: 10.1038/cdd.2008.176. Epub 2009 Jan 9. Cell Death Differ. 2009. PMID: 19136939

6

Functional implications of T cell receptor diversity.

Turner SJ, La Gruta NL, Kedzierska K, Thomas PG, Doherty PC. Turner SJ, et al. Among authors: la gruta nl. Curr Opin Immunol. 2009 Jun;21(3):286-90. doi: 10.1016/j.coi.2009.05.004. Epub 2009 Jun 11. Curr Opin Immunol. 2009. PMID: 19524428 Free PMC article. Review.

7

Altered CD8(+) T cell immunodominance after vaccinia virus infection and the naive repertoire in inbred and F(1) mice.

Flesch IE, Woo WP, Wang Y, Panchanathan V, Wong YC, La Gruta NL, Cukalac T, Tscharke DC. Flesch IE, et al. Among authors: la gruta nl. J Immunol. 2010 Jan 1;184(1):45-55. doi: 10.4049/jimmunol.0900999. Epub 2009 Nov 30. J Immunol. 2010. PMID: 19949110 Free PMC article.

8

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion.

La Gruta NL, Rothwell WT, Cukalac T, Swan NG, Valkenburg SA, Kedzierska K, Thomas PG, Doherty PC, Turner SJ. La Gruta NL, et al. J Clin Invest. 2010 Jun;120(6):1885-94. doi: 10.1172/JCI41538. Epub 2010 May 3. J Clin Invest. 2010. PMID: 20440073 Free PMC article.

9

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.

Valkenburg SA, Gras S, Guillonneau C, La Gruta NL, Thomas PG, Purcell AW, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K. Valkenburg SA, et al. Among authors: la gruta nl. PLoS Pathog. 2010 Aug 12;6(8):e1001039. doi: 10.1371/journal.ppat.1001039. PLoS Pathog. 2010. PMID: 20711359 Free PMC article.

10

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.

Pang SS, Berry R, Chen Z, Kjer-Nielsen L, Perugini MA, King GF, Wang C, Chew SH, La Gruta NL, Williams NK, Beddoe T, Tiganis T, Cowieson NP, Godfrey DI, Purcell AW, Wilce MC, McCluskey J, Rossjohn J. Pang SS, et al. Among authors: la gruta nl. Nature. 2010 Oct 14;467(7317):844-8. doi: 10.1038/nature09448. Nature. 2010. PMID: 20944746

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