La Spada AR - Search Results

1

Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration.

Garden GA, La Spada AR. Garden GA, et al. Among authors: la spada ar. Cerebellum. 2008;7(2):138-49. doi: 10.1007/s12311-008-0027-y. Cerebellum. 2008. PMID: 18418675 Free PMC article. Review.

2

Trinucleotide repeat instability: genetic features and molecular mechanisms.

La Spada AR. La Spada AR. Brain Pathol. 1997 Jul;7(3):943-63. doi: 10.1111/j.1750-3639.1997.tb00895.x. Brain Pathol. 1997. PMID: 9217977 Free PMC article. Review.

3

Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7.

La Spada AR, Fu YH, Sopher BL, Libby RT, Wang X, Li LY, Einum DD, Huang J, Possin DE, Smith AC, Martinez RA, Koszdin KL, Treuting PM, Ware CB, Hurley JB, Ptácek LJ, Chen S. La Spada AR, et al. Neuron. 2001 Sep 27;31(6):913-27. doi: 10.1016/s0896-6273(01)00422-6. Neuron. 2001. PMID: 11580893 Free article.

4

Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

Garden GA, Libby RT, Fu YH, Kinoshita Y, Huang J, Possin DE, Smith AC, Martinez RA, Fine GC, Grote SK, Ware CB, Einum DD, Morrison RS, Ptacek LJ, Sopher BL, La Spada AR. Garden GA, et al. Among authors: la spada ar. J Neurosci. 2002 Jun 15;22(12):4897-905. doi: 10.1523/JNEUROSCI.22-12-04897.2002. J Neurosci. 2002. PMID: 12077187 Free PMC article.

5

Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice.

Libby RT, Monckton DG, Fu YH, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, La Spada AR. Libby RT, et al. Among authors: la spada ar. Hum Mol Genet. 2003 Jan 1;12(1):41-50. doi: 10.1093/hmg/ddg006. Hum Mol Genet. 2003. PMID: 12490531

6

Polyglutamines placed into context.

La Spada AR, Taylor JP. La Spada AR, et al. Neuron. 2003 Jun 5;38(5):681-4. doi: 10.1016/s0896-6273(03)00328-3. Neuron. 2003. PMID: 12797953 Free article. Review.

7

Insights into the molecular basis of polyglutamine neurodegeneration from studies of a spinocerebellar ataxia type 7 mouse model.

Grote SK, La Spada AR. Grote SK, et al. Among authors: la spada ar. Cytogenet Genome Res. 2003;100(1-4):164-74. doi: 10.1159/000072851. Cytogenet Genome Res. 2003. PMID: 14526177 Review.

8

A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage.

Jackson SM, Whitworth AJ, Greene JC, Libby RT, Baccam SL, Pallanck LJ, La Spada AR. Jackson SM, et al. Among authors: la spada ar. Gene. 2005 Feb 28;347(1):35-41. doi: 10.1016/j.gene.2004.12.008. Gene. 2005. PMID: 15715978

9

Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

Custer SK, Garden GA, Gill N, Rueb U, Libby RT, Schultz C, Guyenet SJ, Deller T, Westrum LE, Sopher BL, La Spada AR. Custer SK, et al. Among authors: la spada ar. Nat Neurosci. 2006 Oct;9(10):1302-11. doi: 10.1038/nn1750. Epub 2006 Aug 27. Nat Neurosci. 2006. PMID: 16936724

10

Neurodegeneration: a case of arrested development?

La Spada AR. La Spada AR. Cell. 2006 Nov 17;127(4):669-71. doi: 10.1016/j.cell.2006.11.010. Cell. 2006. PMID: 17110325 Free article.

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