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Hepatic lipase gene variation is related to coronary reactivity in healthy young men.
Fan Y, Laaksonen R, Janatuinen T, Vesalainen R, Nuutila P, Koivula T, Knuuti J, Lehtimäki T. Fan Y, et al. Eur J Clin Invest. 2001 Jul;31(7):574-80. doi: 10.1046/j.1365-2362.2001.00858.x. Eur J Clin Invest. 2001. PMID: 11454011
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine.
Valkonen VP, Päivä H, Salonen JT, Lakka TA, Lehtimäki T, Laakso J, Laaksonen R. Valkonen VP, et al. Lancet. 2001 Dec 22-29;358(9299):2127-8. doi: 10.1016/S0140-6736(01)07184-7. Lancet. 2001. PMID: 11784629
High oxidized LDL and elevated plasma homocysteine contribute to the early reduction of myocardial flow reserve in healthy adults.
Laaksonen R, Janatuinen T, Vesalainen R, Lehtimäki T, Elovaara I, Jaakkola O, Jokela H, Laakso J, Nuutila P, Punnonen K, Raitakari O, Saikku P, Salminen K, Knuuti J. Laaksonen R, et al. Eur J Clin Invest. 2002 Nov;32(11):795-802. doi: 10.1046/j.1365-2362.2002.01051.x. Eur J Clin Invest. 2002. PMID: 12423319
Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study.
Kunnas TA, Lehtimäki T, Laaksonen R, Ilveskoski E, Janatuinen T, Vesalainen R, Nuutila P, Karhunen PJ, Knuuti J, Nikkari ST. Kunnas TA, et al. J Mol Med (Berl). 2002 Dec;80(12):802-7. doi: 10.1007/s00109-002-0398-3. Epub 2002 Nov 22. J Mol Med (Berl). 2002. PMID: 12483466 Clinical Trial.
Myeloperoxidase gene variation and coronary flow reserve in young healthy men.
Mäkelä R, Laaksonen R, Janatuinen T, Vesalainen R, Nuutila P, Jaakkola O, Knuuti J, Lehtimäki T. Mäkelä R, et al. J Biomed Sci. 2004 Jan-Feb;11(1):59-64. doi: 10.1007/BF02256549. J Biomed Sci. 2004. PMID: 14730210
A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle.
Laaksonen R, Katajamaa M, Päivä H, Sysi-Aho M, Saarinen L, Junni P, Lütjohann D, Smet J, Van Coster R, Seppänen-Laakso T, Lehtimäki T, Soini J, Oresic M. Laaksonen R, et al. PLoS One. 2006 Dec 20;1(1):e97. doi: 10.1371/journal.pone.0000097. PLoS One. 2006. PMID: 17183729 Free PMC article. Clinical Trial.
Plasma asymmetric dimethylarginine and retinal vessel diameters in middle-aged men.
Hemminki V, Laakso J, Kähönen M, Turjanmaa V, Uusitalo H, Lehtimäki T, Ruokonen I, Laaksonen R, Huhtala H, Päivä H. Hemminki V, et al. Metabolism. 2007 Oct;56(10):1305-10. doi: 10.1016/j.metabol.2007.05.012. Metabolism. 2007. PMID: 17884437
Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs.
Jänis MT, Laaksonen R, Oresic M. Jänis MT, et al. Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):665-80. doi: 10.1517/17425255.4.6.665. Expert Opin Drug Metab Toxicol. 2008. PMID: 18611110 Review.
Lipidomics-based safety biomarkers for lipid-lowering treatments.
Laaksonen R, Jänis MT, Oresic M. Laaksonen R, et al. Angiology. 2008 Apr-May;59(2 Suppl):65S-8S. doi: 10.1177/0003319708321106. Epub 2008 Jul 16. Angiology. 2008. PMID: 18632766 Review.
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