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(S)-1-(Pent-4'-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling.
J Enzyme Inhib Med Chem. 2014 Oct;29(5):654-62. doi: 10.3109/14756366.2013.837900. Epub 2013 Oct 9.
J Enzyme Inhib Med Chem. 2014.
PMID: 24102523
The unexpected 1000-fold decrease in activity of 2a comparatively to the known regioisomeric structure 1a (i.e. lipophilic chains placed on N1 and C3 positions of the beta-lactam core) could be explained on the basis of docking studies into a revisited model of hFAAH activ …
The unexpected 1000-fold decrease in activity of 2a comparatively to the known regioisomeric structure 1a (i.e. lipophilic chains placed on …
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