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221 results

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Page 1
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.
Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis. Goldstein B, et al. Pediatr Crit Care Med. 2005 Jan;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. Pediatr Crit Care Med. 2005. PMID: 15636651 Review.
c) What are the specific definitions of pediatric organ failure and the validity of pediatric organ failure scores? d) What are the appropriate study populations and study end points required to successfully conduct clinical trials in pediatric sepsis? ...RESULTS: Conferen …
c) What are the specific definitions of pediatric organ failure and the validity of pediatric organ failure scores? d) What are the a …
Febrile infants risk score at triage (FIRST) for the early identification of serious bacterial infections.
Chong SL, Niu C, Ong GY, Piragasam R, Khoo ZX, Koh ZX, Guo D, Lee JH, Ong MEH, Liu N. Chong SL, et al. Sci Rep. 2023 Sep 22;13(1):15845. doi: 10.1038/s41598-023-42854-z. Sci Rep. 2023. PMID: 37740004 Free PMC article.
We aimed to derive the Febrile Infants Risk Score at Triage (FIRST) to quantify risk for serious bacterial infections (SBIs), defined as bacteremia, meningitis and urinary tract infections. ...In the testing dataset, FIRST + had an area under receiver operati …
We aimed to derive the Febrile Infants Risk Score at Triage (FIRST) to quantify risk for serious bacterial infections ( …
Management of Fever in Infants and Young Children.
Hamilton JL, Evans SG, Bakshi M. Hamilton JL, et al. Am Fam Physician. 2020 Jun 15;101(12):721-729. Am Fam Physician. 2020. PMID: 32538597 Free article.
Despite dramatic reductions in the rates of bacteremia and meningitis since the 1980s, febrile illness in children younger than 36 months continues to be a concern with potentially serious consequences. ...Lumbar puncture is not recommended for children older than three mo …
Despite dramatic reductions in the rates of bacteremia and meningitis since the 1980s, febrile illness in children younger than 36 mo …
Validation of the "Step-by-Step" Approach in the Management of Young Febrile Infants.
Gomez B, Mintegi S, Bressan S, Da Dalt L, Gervaix A, Lacroix L; European Group for Validation of the Step-by-Step Approach. Gomez B, et al. Pediatrics. 2016 Aug;138(2):e20154381. doi: 10.1542/peds.2015-4381. Epub 2016 Jul 5. Pediatrics. 2016. PMID: 27382134
BACKGROUND: A sequential approach to young febrile infants on the basis of clinical and laboratory parameters, including procalcitonin, was recently described as an accurate tool in identifying patients at risk for invasive bacterial infection (IBI). ...CONCL …
BACKGROUND: A sequential approach to young febrile infants on the basis of clinical and laboratory parameters, includin …
External Validation of an Invasive Bacterial Infection Score for Young Febrile Infants.
Tsai SJ, Ramgopal S. Tsai SJ, et al. Hosp Pediatr. 2021 Mar;11(3):239-244. doi: 10.1542/hpeds.2020-003178. Hosp Pediatr. 2021. PMID: 33602794
Infants were excluded if they had clinical sepsis or chronic conditions or were missing any laboratory components of the Aronson score. ...Our findings suggest that the rule may be generalizable for the risk stratification of well-appearing febrile …
Infants were excluded if they had clinical sepsis or chronic conditions or were missing any laboratory components of the Arons …
Genotype-phenotype associations in SCN1A-related epilepsies.
Zuberi SM, Brunklaus A, Birch R, Reavey E, Duncan J, Forbes GH. Zuberi SM, et al. Neurology. 2011 Feb 15;76(7):594-600. doi: 10.1212/WNL.0b013e31820c309b. Epub 2011 Jan 19. Neurology. 2011. PMID: 21248271
OBJECTIVE: Most mutations in SCN1A-related epilepsies are novel and when an infant presents with febrile seizures (FS) it is uncertain if they will have simple FS, FS+, or develop a severe epilepsy such as Dravet syndrome. ...METHODS: We retrospectively evaluated cl …
OBJECTIVE: Most mutations in SCN1A-related epilepsies are novel and when an infant presents with febrile seizures (FS) it is u …
Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial.
Thompson RJ, Arnell H, Artan R, Baumann U, Calvo PL, Czubkowski P, Dalgic B, D'Antiga L, Durmaz Ö, Fischler B, Gonzalès E, Grammatikopoulos T, Gupte G, Hardikar W, Houwen RHJ, Kamath BM, Karpen SJ, Kjems L, Lacaille F, Lachaux A, Lainka E, Mack CL, Mattsson JP, McKiernan P, Özen H, Rajwal SR, Roquelaure B, Shagrani M, Shteyer E, Soufi N, Sturm E, Tessier ME, Verkade HJ, Horn P. Thompson RJ, et al. Lancet Gastroenterol Hepatol. 2022 Sep;7(9):830-842. doi: 10.1016/S2468-1253(22)00093-0. Epub 2022 Jul 1. Lancet Gastroenterol Hepatol. 2022. PMID: 35780807 Free article. Clinical Trial.
Two primary endpoints were evaluated: proportion of positive pruritus assessments (PPAs; ie, scratching score of 1 or 1-point decrease as assessed by caregivers using the Albireo observer-reported outcome [ObsRO] PRUCISION instrument) over 24 weeks, and proportion of patie …
Two primary endpoints were evaluated: proportion of positive pruritus assessments (PPAs; ie, scratching score of 1 or 1-point decreas …
Performance of Febrile Infant Decision Tools on Hypothermic Infants Evaluated for Infection.
Westphal K, Adib H, Doraiswamy V, Basiago K, Lee J, Banker SL, Morrison J, McCartor S, Berger S, Schmit EO, Van Meurs A, Mitchell M, Lee C, Wood JK, Tapp LG, Kunkel D, Halvorson EE, Potisek NM; Hypothermic Young Infant Research Collaborative. Westphal K, et al. Hosp Pediatr. 2024 Mar 1;14(3):163-171. doi: 10.1542/hpeds.2023-007525. Hosp Pediatr. 2024. PMID: 38312006
BACKGROUND: Given the lack of evidence-based guidelines for hypothermic infants, providers may be inclined to use febrile infant decision-making tools to guide management decisions. Our objective was to assess the diagnostic performance of febrile i …
BACKGROUND: Given the lack of evidence-based guidelines for hypothermic infants, providers may be inclined to use febrile i …
The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants.
Nigrovic LE, Mahajan PV, Blumberg SM, Browne LR, Linakis JG, Ruddy RM, Bennett JE, Rogers AJ, Tzimenatos L, Powell EC, Alpern ER, Casper TC, Ramilo O, Kuppermann N; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN). Nigrovic LE, et al. Pediatrics. 2017 Jul;140(1):e20170695. doi: 10.1542/peds.2017-0695. Epub 2017 Jun 6. Pediatrics. 2017. PMID: 28759413 Free PMC article.
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile infants 60 days of age with and without serious bacterial infections (SBIs). ...More accurate clinical and laboratory …
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify f …
A Comparison of Temperature Thresholds to Begin Laboratory Evaluation of Well-Appearing Febrile Infants.
Lam S, Chamdawala H, Friedman J, Meltzer JA. Lam S, et al. Pediatr Emerg Care. 2022 Nov 1;38(11):628-632. doi: 10.1097/PEC.0000000000002821. Epub 2022 Aug 18. Pediatr Emerg Care. 2022. PMID: 35981325
OBJECTIVE: Young infants who develop fever are at an increased risk for serious infection. It is unclear, however, what temperature cutoff would be optimal to begin evaluating these infants because some criteria use different thresholds. ...Using an evaluatio …
OBJECTIVE: Young infants who develop fever are at an increased risk for serious infection. It is unclear, however, what temper …
221 results