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The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells.
Nueda ML, Naranjo AI, Baladrón V, Laborda J. Nueda ML, et al. Biochim Biophys Acta. 2014 Nov;1843(11):2674-84. doi: 10.1016/j.bbamcr.2014.07.015. Epub 2014 Aug 2. Biochim Biophys Acta. 2014. PMID: 25093684
Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.
Notari L, Baladron V, Aroca-Aguilar JD, Balko N, Heredia R, Meyer C, Notario PM, Saravanamuthu S, Nueda ML, Sanchez-Sanchez F, Escribano J, Laborda J, Becerra SP. Notari L, et al. J Biol Chem. 2006 Dec 8;281(49):38022-37. doi: 10.1074/jbc.M600353200. Epub 2006 Oct 10. J Biol Chem. 2006. PMID: 17032652
The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.
Sánchez-Solana B, Nueda ML, Ruvira MD, Ruiz-Hidalgo MJ, Monsalve EM, Rivero S, García-Ramírez JJ, Díaz-Guerra MJ, Baladrón V, Laborda J. Sánchez-Solana B, et al. Biochim Biophys Acta. 2011 Jun;1813(6):1153-64. doi: 10.1016/j.bbamcr.2011.03.004. Epub 2011 Mar 15. Biochim Biophys Acta. 2011. PMID: 21419176
dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats.
Baladrón V, Ruiz-Hidalgo MJ, Nueda ML, Díaz-Guerra MJ, García-Ramírez JJ, Bonvini E, Gubina E, Laborda J. Baladrón V, et al. Exp Cell Res. 2005 Feb 15;303(2):343-59. doi: 10.1016/j.yexcr.2004.10.001. Epub 2004 Nov 2. Exp Cell Res. 2005. PMID: 15652348
The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system.
Baladrón V, Ruiz-Hidalgo MJ, Bonvini E, Gubina E, Notario V, Laborda J. Baladrón V, et al. Biochem Biophys Res Commun. 2002 Feb 22;291(2):193-204. doi: 10.1006/bbrc.2002.6431. Biochem Biophys Res Commun. 2002. PMID: 11846389
Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk.
Garcés C, Ruiz-Hidalgo MJ, Bonvini E, Goldstein J, Laborda J. Garcés C, et al. Differentiation. 1999 Jan;64(2):103-14. doi: 10.1046/j.1432-0436.1999.6420103.x. Differentiation. 1999. PMID: 10234807
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