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Tumorigenic activity of rho genes from Aplysia californica.
Perona R, Esteve P, Jiménez B, Ballestero RP, Ramón y Cajal S, Lacal JC. Perona R, et al. Among authors: lacal jc. Oncogene. 1993 May;8(5):1285-92. Oncogene. 1993. PMID: 8479750
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers.
Ramírez de Molina A, Rodríguez-González A, Gutiérrez R, Martínez-Piñeiro L, Sánchez J, Bonilla F, Rosell R, Lacal J. Ramírez de Molina A, et al. Among authors: lacal j. Biochem Biophys Res Commun. 2002 Aug 23;296(3):580-3. doi: 10.1016/s0006-291x(02)00920-8. Biochem Biophys Res Commun. 2002. PMID: 12176020
From Ras signalling to ChoK inhibitors: a further advance in anticancer drug design.
Ramírez de Molina A, Rodríguez-González A, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Cancer Lett. 2004 Apr 8;206(2):137-48. doi: 10.1016/j.canlet.2003.08.031. Cancer Lett. 2004. PMID: 15013519 Review.
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Gómez Del Pulgar T, Valdés-Mora F, Bandrés E, Pérez-Palacios R, Espina C, Cejas P, García-Cabezas MA, Nistal M, Casado E, González-Barón M, García-Foncillas J, Lacal JC. Gómez Del Pulgar T, et al. Among authors: lacal jc. Int J Oncol. 2008 Jul;33(1):185-93. Int J Oncol. 2008. PMID: 18575765
Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer.
Gómez del Pulgar T, Bandrés E, Espina C, Valdés-Mora F, Pérez-Palacios R, García-Amigot F, García-Foncillas J, Lacal JC. Gómez del Pulgar T, et al. Among authors: lacal jc. Int J Biochem Cell Biol. 2007;39(12):2289-302. doi: 10.1016/j.biocel.2007.06.014. Epub 2007 Jul 4. Int J Biochem Cell Biol. 2007. PMID: 17766170
A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells.
Espina C, Céspedes MV, García-Cabezas MA, Gómez del Pulgar MT, Boluda A, Oroz LG, Benitah SA, Cejas P, Nistal M, Mangues R, Lacal JC. Espina C, et al. Among authors: lacal jc. Am J Pathol. 2008 Jan;172(1):156-66. doi: 10.2353/ajpath.2008.070561. Epub 2007 Dec 28. Am J Pathol. 2008. PMID: 18165265 Free PMC article.
Choline kinase is a novel oncogene that potentiates RhoA-induced carcinogenesis.
Ramírez de Molina A, Gallego-Ortega D, Sarmentero J, Bañez-Coronel M, Martín-Cantalejo Y, Lacal JC. Ramírez de Molina A, et al. Among authors: lacal jc. Cancer Res. 2005 Jul 1;65(13):5647-53. doi: 10.1158/0008-5472.CAN-04-4416. Cancer Res. 2005. PMID: 15994937
Rho GTPase expression in tumourigenesis: evidence for a significant link.
Gómez del Pulgar T, Benitah SA, Valerón PF, Espina C, Lacal JC. Gómez del Pulgar T, et al. Among authors: lacal jc. Bioessays. 2005 Jun;27(6):602-13. doi: 10.1002/bies.20238. Bioessays. 2005. PMID: 15892119 Review.
Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.
Benitah SA, Valerón PF, van Aelst L, Marshall CJ, Lacal JC. Benitah SA, et al. Among authors: lacal jc. Biochim Biophys Acta. 2004 Dec 17;1705(2):121-32. doi: 10.1016/j.bbcan.2004.10.002. Biochim Biophys Acta. 2004. PMID: 15588766 Review.
Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action.
Rodríguez-González A, Ramirez de Molina A, Fernández F, Lacal JC. Rodríguez-González A, et al. Among authors: lacal jc. Oncogene. 2004 Oct 28;23(50):8247-59. doi: 10.1038/sj.onc.1208045. Oncogene. 2004. PMID: 15378008
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