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Osteoclast differentiation and activation.
Boyle WJ, Simonet WS, Lacey DL. Boyle WJ, et al. Among authors: lacey dl. Nature. 2003 May 15;423(6937):337-42. doi: 10.1038/nature01658. Nature. 2003. PMID: 12748652 Review.
Dickkopf-1 is a master regulator of joint remodeling.
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G. Diarra D, et al. Among authors: lacey d. Nat Med. 2007 Feb;13(2):156-63. doi: 10.1038/nm1538. Epub 2007 Jan 21. Nat Med. 2007. PMID: 17237793
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab.
Lacey DL, Boyle WJ, Simonet WS, Kostenuik PJ, Dougall WC, Sullivan JK, San Martin J, Dansey R. Lacey DL, et al. Nat Rev Drug Discov. 2012 May;11(5):401-19. doi: 10.1038/nrd3705. Nat Rev Drug Discov. 2012. PMID: 22543469 Review.
Sustained antiresorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats.
Capparelli C, Morony S, Warmington K, Adamu S, Lacey D, Dunstan CR, Stouch B, Martin S, Kostenuik PJ. Capparelli C, et al. Among authors: lacey d. J Bone Miner Res. 2003 May;18(5):852-8. doi: 10.1359/jbmr.2003.18.5.852. J Bone Miner Res. 2003. PMID: 12733724
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. Fata JE, et al. Among authors: lacey dl. Cell. 2000 Sep 29;103(1):41-50. doi: 10.1016/s0092-8674(00)00103-3. Cell. 2000. PMID: 11051546
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.
Hofbauer LC, Khosla S, Dunstan CR, Lacey DL, Boyle WJ, Riggs BL. Hofbauer LC, et al. Among authors: lacey dl. J Bone Miner Res. 2000 Jan;15(1):2-12. doi: 10.1359/jbmr.2000.15.1.2. J Bone Miner Res. 2000. PMID: 10646108 Review.
Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis.
Hofbauer LC, Gori F, Riggs BL, Lacey DL, Dunstan CR, Spelsberg TC, Khosla S. Hofbauer LC, et al. Among authors: lacey dl. Endocrinology. 1999 Oct;140(10):4382-9. doi: 10.1210/endo.140.10.7034. Endocrinology. 1999. PMID: 10499489
A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta, TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3.
Morony S, Capparelli C, Lee R, Shimamoto G, Boone T, Lacey DL, Dunstan CR. Morony S, et al. Among authors: lacey dl. J Bone Miner Res. 1999 Sep;14(9):1478-85. doi: 10.1359/jbmr.1999.14.9.1478. J Bone Miner Res. 1999. PMID: 10469275
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM. Kong YY, et al. Among authors: lacey dl. Nature. 1999 Nov 18;402(6759):304-9. doi: 10.1038/46303. Nature. 1999. PMID: 10580503
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis.
Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. Kong YY, et al. Among authors: lacey dl. Nature. 1999 Jan 28;397(6717):315-23. doi: 10.1038/16852. Nature. 1999. PMID: 9950424
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