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Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.
Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z. Lachance V, et al. Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4. Mol Neurodegener. 2019. PMID: 31775806 Free PMC article.
Autophagy Receptors and Neurodegenerative Diseases.
Deng Z, Purtell K, Lachance V, Wold MS, Chen S, Yue Z. Deng Z, et al. Among authors: lachance v. Trends Cell Biol. 2017 Jul;27(7):491-504. doi: 10.1016/j.tcb.2017.01.001. Epub 2017 Feb 3. Trends Cell Biol. 2017. PMID: 28169082 Review.
ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models.
Wold MS, Lim J, Lachance V, Deng Z, Yue Z. Wold MS, et al. Among authors: lachance v. Mol Neurodegener. 2016 Dec 9;11(1):76. doi: 10.1186/s13024-016-0141-0. Mol Neurodegener. 2016. PMID: 27938392 Free PMC article.
A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects.
Zhang J, Lachance V, Schaffner A, Li X, Fedick A, Kaye LE, Liao J, Rosenfeld J, Yachelevich N, Chu ML, Mitchell WG, Boles RG, Moran E, Tokita M, Gorman E, Bagley K, Zhang W, Xia F, Leduc M, Yang Y, Eng C, Wong LJ, Schiffmann R, Diaz GA, Kornreich R, Thummel R, Wasserstein M, Yue Z, Edelmann L. Zhang J, et al. Among authors: lachance v. PLoS Genet. 2016 Apr 27;12(4):e1005848. doi: 10.1371/journal.pgen.1005848. eCollection 2016 Apr. PLoS Genet. 2016. PMID: 27120463 Free PMC article.
New insights in the regulation of Rab GTPases by G protein-coupled receptors.
Lachance V, Angers S, Parent JL. Lachance V, et al. Small GTPases. 2014;5:e29039. doi: 10.4161/sgtp.29039. Epub 2014 May 9. Small GTPases. 2014. PMID: 24950538 Free PMC article.
Ubiquitylation and activation of a Rab GTPase is promoted by a β₂AR-HACE1 complex.
Lachance V, Degrandmaison J, Marois S, Robitaille M, Génier S, Nadeau S, Angers S, Parent JL. Lachance V, et al. J Cell Sci. 2014 Jan 1;127(Pt 1):111-23. doi: 10.1242/jcs.132944. Epub 2013 Nov 4. J Cell Sci. 2014. PMID: 24190883 Free article.
Regulation of β2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor.
Lachance V, Cartier A, Génier S, Munger S, Germain P, Labrecque P, Parent JL. Lachance V, et al. J Biol Chem. 2011 Nov 25;286(47):40802-13. doi: 10.1074/jbc.M111.267815. Epub 2011 Oct 11. J Biol Chem. 2011. PMID: 21990357 Free PMC article.
Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
Li S, Esterberg R, Lachance V, Ren D, Radde-Gallwitz K, Chi F, Parent JL, Fritz A, Chen P. Li S, et al. Among authors: lachance v. Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2264-9. doi: 10.1073/pnas.1013170108. Epub 2011 Jan 24. Proc Natl Acad Sci U S A. 2011. PMID: 21262816 Free PMC article.
The ethics of blood testing as an element of doping control in sport.
Browne A, Lachance V, Pipe A. Browne A, et al. Among authors: lachance v. Med Sci Sports Exerc. 1999 Apr;31(4):497-501. doi: 10.1097/00005768-199904000-00001. Med Sci Sports Exerc. 1999. PMID: 10211842
Type and screen for elective surgery. Results of one year's experience in a small community hospital.
Lee K, Lachance V. Lee K, et al. Among authors: lachance v. Transfusion. 1980 May-Jun;20(3):324-6. doi: 10.1046/j.1537-2995.1980.20380214900.x. Transfusion. 1980. PMID: 7385328