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Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects.
Lachmandas E, Eckold C, Böhme J, Koeken VACM, Marzuki MB, Blok B, Arts RJW, Chen J, Teng KWW, Ratter J, Smolders EJ, Van den Heuvel C, Stienstra R, Dockrell HM, Newell E, Netea MG, Singhal A, Cliff JM, Van Crevel R. Lachmandas E, et al. J Infect Dis. 2019 Jun 5;220(1):139-150. doi: 10.1093/infdis/jiz064. J Infect Dis. 2019. PMID: 30753544 Free PMC article.
Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis.
Lachmandas E, Rios-Miguel AB, Koeken VACM, van der Pasch E, Kumar V, Matzaraki V, Li Y, Oosting M, Joosten LAB, Notebaart RA, Noursadeghi M, Netea MG, van Crevel R, Pollara G. Lachmandas E, et al. J Infect Dis. 2018 Jun 5;218(1):165-170. doi: 10.1093/infdis/jiy173. J Infect Dis. 2018. PMID: 29618104 Free PMC article.
Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.
Böhme J, Martinez N, Li S, Lee A, Marzuki M, Tizazu AM, Ackart D, Frenkel JH, Todd A, Lachmandas E, Lum J, Shihui F, Ng TP, Lee B, Larbi A, Netea MG, Basaraba R, van Crevel R, Newell E, Kornfeld H, Singhal A. Böhme J, et al. Among authors: lachmandas e. Nat Commun. 2020 Oct 16;11(1):5225. doi: 10.1038/s41467-020-19095-z. Nat Commun. 2020. PMID: 33067434 Free PMC article.
Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis.
Eckold C, Kumar V, Weiner J, Alisjahbana B, Riza AL, Ronacher K, Coronel J, Kerry-Barnard S, Malherbe ST, Kleynhans L, Stanley K, Ruslami R, Ioana M, Ugarte-Gil C, Walzl G, van Crevel R, Wijmenga C, Critchley JA, Dockrell HM, Cliff JM; TANDEM consortium. Eckold C, et al. Clin Infect Dis. 2021 Jan 23;72(1):69-78. doi: 10.1093/cid/ciaa751. Clin Infect Dis. 2021. PMID: 32533832 Free PMC article.
Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype.
van Laarhoven A, Mandemakers JJ, Kleinnijenhuis J, Enaimi M, Lachmandas E, Joosten LA, Ottenhoff TH, Netea MG, van Soolingen D, van Crevel R. van Laarhoven A, et al. Among authors: lachmandas e. Infect Immun. 2013 Oct;81(10):3750-6. doi: 10.1128/IAI.00282-13. Epub 2013 Jul 29. Infect Immun. 2013. PMID: 23897611 Free PMC article.
Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells.
Lachmandas E, Beigier-Bompadre M, Cheng SC, Kumar V, van Laarhoven A, Wang X, Ammerdorffer A, Boutens L, de Jong D, Kanneganti TD, Gresnigt MS, Ottenhoff TH, Joosten LA, Stienstra R, Wijmenga C, Kaufmann SH, van Crevel R, Netea MG. Lachmandas E, et al. Eur J Immunol. 2016 Nov;46(11):2574-2586. doi: 10.1002/eji.201546259. Epub 2016 Sep 27. Eur J Immunol. 2016. PMID: 27624090 Free PMC article.
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