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Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship.
J Med Chem. 2007 Sep 20;50(19):4572-84. doi: 10.1021/jm070143x. Epub 2007 Aug 28.
J Med Chem. 2007.
PMID: 17722899
Substituted benzimidazoles with nanomolar activity against respiratory syncytial virus.
Andries K, Moeremans M, Gevers T, Willebrords R, Sommen C, Lacrampe J, Janssens F, Wyde PR.
Andries K, et al. Among authors: lacrampe j.
Antiviral Res. 2003 Nov;60(3):209-19. doi: 10.1016/j.antiviral.2003.07.004.
Antiviral Res. 2003.
PMID: 14638397
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Synthesis and biological evaluation of 1,2,4-triazinylphenylalkylthiazolecarboxylic acid esters as cytokine-inhibiting antedrugs with strong bronchodilating effects in an animal model of asthma.
Freyne EJ, Lacrampe JF, Deroose F, Boeckx GM, Willems M, Embrechts W, Coesemans E, Willems JJ, Fortin JM, Ligney Y, Dillen LL, Cools WF, Goossens J, Corens D, De Groot A, Van Wauwe JP.
Freyne EJ, et al. Among authors: lacrampe jf.
J Med Chem. 2005 Mar 24;48(6):2167-75. doi: 10.1021/jm049479m.
J Med Chem. 2005.
PMID: 15771459
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Identification of R146225 as a novel, orally active inhibitor of interleukin-5 biosynthesis.
Van Wauwe J, Aerts F, Cools M, Deroose F, Freyne E, Goossens J, Hermans B, Lacrampe J, Van Genechten H, Van Gerven F, Van Nyen G.
Van Wauwe J, et al. Among authors: lacrampe j.
J Pharmacol Exp Ther. 2000 Nov;295(2):655-61.
J Pharmacol Exp Ther. 2000.
PMID: 11046102
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