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74 results

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Page 1
Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity.
Lica JJ, Gucwa K, Heldt M, Stupak A, Maciejewska N, Ptaszyńska N, Łęgowska A, Pradhan B, Gitlin-Domagalska A, Dębowski D, Jakóbkiewicz-Banecka J, Rolka K. Lica JJ, et al. Molecules. 2024 Feb 1;29(3):678. doi: 10.3390/molecules29030678. Molecules. 2024. PMID: 38338422 Free PMC article.
The fusion of penetrating peptides (PPs), e.g., cell penetration peptides (CPPs) or antimicrobial peptides (AMPs), together with antimicrobial agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong ant …
The fusion of penetrating peptides (PPs), e.g., cell penetration peptides (CPPs) or antimicrobial peptides (AMPs), together with antimicrobi …
Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin.
Hwang PM, Zhou N, Shan X, Arrowsmith CH, Vogel HJ. Hwang PM, et al. Biochemistry. 1998 Mar 24;37(12):4288-98. doi: 10.1021/bi972323m. Biochemistry. 1998. PMID: 9521752
The NMR structure of LfcinB reveals a somewhat distorted antiparallel beta-sheet. This contrasts with the X-ray structure of bovine lactoferrin, in which residues 1-13 (of LfcinB) form an alpha-helix. Hence, this region of lactoferricin B appears able …
The NMR structure of LfcinB reveals a somewhat distorted antiparallel beta-sheet. This contrasts with the X-ray structure of bovine l …
Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD-L1.
Zhang P, Liu J, Li W, Li S, Han X. Zhang P, et al. Cancer Med. 2018 Jul;7(7):3178-3187. doi: 10.1002/cam4.1529. Epub 2018 May 15. Cancer Med. 2018. PMID: 29761938 Free PMC article.
This study is to investigate the programmed death-ligand 1 (PD-L1) expression in HNSCC, and test the effect of lactoferricin B (LfcinB) on chemoresistance and its mechanism. We analyzed 510 HNSCC patients in TCGA database and investigated how CD274 expression …
This study is to investigate the programmed death-ligand 1 (PD-L1) expression in HNSCC, and test the effect of lactoferricin B …
Membrane potential is vital for rapid permeabilization of plasma membranes and lipid bilayers by the antimicrobial peptide lactoferricin B.
Hossain F, Moghal MMR, Islam MZ, Moniruzzaman M, Yamazaki M. Hossain F, et al. J Biol Chem. 2019 Jul 5;294(27):10449-10462. doi: 10.1074/jbc.RA119.007762. Epub 2019 May 22. J Biol Chem. 2019. PMID: 31118274 Free PMC article.
Lactoferricin B (LfcinB) is a cationic antimicrobial peptide, and its capacity to damage the bacterial plasma membrane is suggested to be a main factor in LfcinB's antimicrobial activity. ...LfcinB induced rapid calcein leakage from single E. co …
Lactoferricin B (LfcinB) is a cationic antimicrobial peptide, and its capacity to damage the bacterial plasma membrane …
Lactoferricin B-derived peptides with inhibitory effects on ECE-dependent vasoconstriction.
Fernández-Musoles R, López-Díez JJ, Torregrosa G, Vallés S, Alborch E, Manzanares P, Salom JB. Fernández-Musoles R, et al. Peptides. 2010 Oct;31(10):1926-33. doi: 10.1016/j.peptides.2010.06.024. Epub 2010 Jun 30. Peptides. 2010. PMID: 20600419
ECE inhibition could be beneficial in the treatment of hypertension. In this study, a set of eight lactoferricin B (LfcinB)-derived peptides, previously characterized in our laboratory as angiotensin-converting enzyme (ACE) inhibitory peptides, was examined f …
ECE inhibition could be beneficial in the treatment of hypertension. In this study, a set of eight lactoferricin B (LfcinB …
Antihypertensive properties of lactoferricin B-derived peptides.
Ruiz-Giménez P, Ibáñez A, Salom JB, Marcos JF, López-Díez JJ, Vallés S, Torregrosa G, Alborch E, Manzanares P. Ruiz-Giménez P, et al. J Agric Food Chem. 2010 Jun 9;58(11):6721-7. doi: 10.1021/jf100899u. J Agric Food Chem. 2010. PMID: 20446662
A set of eight lactoferricin B (LfcinB)-derived peptides was examined for inhibitory effects on angiotensin I-converting enzyme (ACE) activity and ACE-dependent vasoconstriction, and their hypotensive effect in spontaneously hypertensive rats (SHR). Peptides …
A set of eight lactoferricin B (LfcinB)-derived peptides was examined for inhibitory effects on angiotensin I-convertin …
Bovine lactoferricin induces caspase-independent apoptosis in human B-lymphoma cells and extends the survival of immune-deficient mice bearing B-lymphoma xenografts.
Furlong SJ, Mader JS, Hoskin DW. Furlong SJ, et al. Exp Mol Pathol. 2010 Jun;88(3):371-5. doi: 10.1016/j.yexmp.2010.02.001. Epub 2010 Feb 18. Exp Mol Pathol. 2010. PMID: 20171209
LfcinB killed B-lymphoma cells more efficiently at low serum concentrations and was inhibited in the presence of exogenous bovine serum albumin, suggesting partial neutralization of cationic LfcinB by anionic serum components. LfcinB-induced apoptosis in B-ly …
LfcinB killed B-lymphoma cells more efficiently at low serum concentrations and was inhibited in the presence of exogenous bovine ser …
The lactoferricin B-derived peptide, LfB17-34, induces melanogenesis in B16F10 cells.
Huang HC, Lin H, Huang MC. Huang HC, et al. Int J Mol Med. 2017 Mar;39(3):595-602. doi: 10.3892/ijmm.2017.2884. Epub 2017 Feb 9. Int J Mol Med. 2017. PMID: 28204812 Free PMC article.
Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including antimicrobial, antiviral, antioxidant and immunomodulatory activities. However, the role of LfcinB-related peptides in melanogenesis rema …
Lactoferricin B (LfcinB), a peptide of bovine lactoferrin (LfB), exhibits multiple biological functions, including anti …
The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.
Eliassen LT, Berge G, Leknessund A, Wikman M, Lindin I, Løkke C, Ponthan F, Johnsen JI, Sveinbjørnsson B, Kogner P, Flaegstad T, Rekdal Ø. Eliassen LT, et al. Int J Cancer. 2006 Aug 1;119(3):493-500. doi: 10.1002/ijc.21886. Int J Cancer. 2006. PMID: 16572423
In this study the cytotoxic effect of the antimicrobial peptide, LfcinB was tested in a panel of human neuroblastoma cell lines. LfcinB displayed a selective cytotoxic activity against both MYCN-amplified and non-MYCN-amplified cell lines. Non-transformed fibroblast …
In this study the cytotoxic effect of the antimicrobial peptide, LfcinB was tested in a panel of human neuroblastoma cell lines. L …
Effect of membrane potential on entry of lactoferricin B-derived 6-residue antimicrobial peptide into single Escherichia coli cells and lipid vesicles.
Hossain F, Dohra H, Yamazaki M. Hossain F, et al. J Bacteriol. 2021 May 1;203(9):e00021-21. doi: 10.1128/JB.00021-21. Epub 2021 Feb 8. J Bacteriol. 2021. PMID: 33558393 Free PMC article.
The antimicrobial peptide (AMP) derived from lactoferricin B, LfcinB (4-9) (RRWQWR), and lissamine rhodamine B red-labeled peptide (Rh-LfcinB (4-9)) exhibit strong antimicrobial activities, and they can enter Escherichia coli cells without damaging the …
The antimicrobial peptide (AMP) derived from lactoferricin B, LfcinB (4-9) (RRWQWR), and lissamine rhodamine B red-labe …
74 results