Ladd TB - Search Results

1

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates.

Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ, Golde TE. Nyborg AC, et al. Among authors: ladd tb. Mol Neurodegener. 2006 Jun 12;1:3. doi: 10.1186/1750-1326-1-3. Mol Neurodegener. 2006. PMID: 16930450 Free PMC article.

2

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.

Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE. Nyborg AC, et al. Among authors: ladd tb. Mol Neurodegener. 2006 Nov 14;1:16. doi: 10.1186/1750-1326-1-16. Mol Neurodegener. 2006. PMID: 17105660 Free PMC article.

3

Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy.

Levites Y, Funk C, Wang X, Chakrabarty P, McFarland KN, Bramblett B, O'Neal V, Liu X, Ladd T, Robinson M, Allen M, Carrasquillo MM, Dickson D, Cruz P, Ryu D, Li HD, Price ND, Ertekin-Taner N, Golde TE. Levites Y, et al. Mol Neurodegener. 2021 May 6;16(1):32. doi: 10.1186/s13024-021-00453-4. Mol Neurodegener. 2021. PMID: 33957936 Free PMC article.

4

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor.

Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE. Nyborg AC, et al. Among authors: ladd tb. J Biol Chem. 2004 Apr 9;279(15):15153-60. doi: 10.1074/jbc.M309305200. Epub 2004 Jan 2. J Biol Chem. 2004. PMID: 14704149 Free article.

5

A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin.

Nyborg AC, Jansen K, Ladd TB, Fauq A, Golde TE. Nyborg AC, et al. Among authors: ladd tb. J Biol Chem. 2004 Oct 8;279(41):43148-56. doi: 10.1074/jbc.M405879200. Epub 2004 Jul 12. J Biol Chem. 2004. PMID: 15252014 Free article.

6

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.

Nyborg AC, Ladd TB, Jansen K, Kukar T, Golde TE. Nyborg AC, et al. Among authors: ladd tb. FASEB J. 2006 Aug;20(10):1671-9. doi: 10.1096/fj.06-5762com. FASEB J. 2006. PMID: 16873890

7

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.

Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. Jung JI, et al. Among authors: ladd tb. Mol Neurodegener. 2015 Jul 14;10:29. doi: 10.1186/s13024-015-0021-z. Mol Neurodegener. 2015. PMID: 26169917 Free PMC article.

8

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Among authors: ladd tb. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

9

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI. Rutherford NJ, et al. Among authors: ladd tb. Mol Neurodegener. 2015 Jul 30;10:32. doi: 10.1186/s13024-015-0029-4. Mol Neurodegener. 2015. PMID: 26223783 Free PMC article.

10

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.

Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE. Kukar T, et al. Nat Med. 2005 May;11(5):545-50. doi: 10.1038/nm1235. Epub 2005 Apr 17. Nat Med. 2005. PMID: 15834426

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