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The role of dUTPase and uracil-DNA repair in cancer chemotherapy.
Ladner RD. Ladner RD. Curr Protein Pept Sci. 2001 Dec;2(4):361-70. doi: 10.2174/1389203013380991. Curr Protein Pept Sci. 2001. PMID: 12374095 Review.
Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition.
Koehler SE, Ladner RD. Koehler SE, et al. Among authors: ladner rd. Mol Pharmacol. 2004 Sep;66(3):620-6. doi: 10.1124/mol.66.3.. Mol Pharmacol. 2004. PMID: 15322254
A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity.
Mandola MV, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz HJ, Ladner RD. Mandola MV, et al. Among authors: ladner rd. Cancer Res. 2003 Jun 1;63(11):2898-904. Cancer Res. 2003. PMID: 12782596
dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae.
Tinkelenberg BA, Hansbury MJ, Ladner RD. Tinkelenberg BA, et al. Among authors: ladner rd. Cancer Res. 2002 Sep 1;62(17):4909-15. Cancer Res. 2002. PMID: 12208740
hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae.
Elateri I, Tinkelenberg BA, Hansbury M, Caradonna S, Muller-Weeks S, Ladner RD. Elateri I, et al. Among authors: ladner rd. DNA Repair (Amst). 2003 Mar 1;2(3):315-23. doi: 10.1016/s1568-7864(02)00221-5. DNA Repair (Amst). 2003. PMID: 12547394
Identification of sequence determinants of human nuclear dUTPase isoform localization.
Tinkelenberg BA, Fazzone W, Lynch FJ, Ladner RD. Tinkelenberg BA, et al. Among authors: ladner rd. Exp Cell Res. 2003 Jul 1;287(1):39-46. doi: 10.1016/s0014-4827(03)00048-x. Exp Cell Res. 2003. PMID: 12799180
A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels.
Mandola MV, Stoehlmacher J, Zhang W, Groshen S, Yu MC, Iqbal S, Lenz HJ, Ladner RD. Mandola MV, et al. Among authors: ladner rd. Pharmacogenetics. 2004 May;14(5):319-27. doi: 10.1097/00008571-200405000-00007. Pharmacogenetics. 2004. PMID: 15115918
The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species.
Ladner RD, Caradonna SJ. Ladner RD, et al. J Biol Chem. 1997 Jul 25;272(30):19072-80. doi: 10.1074/jbc.272.30.19072. J Biol Chem. 1997. PMID: 9228092
Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase.
Ladner RD, McNulty DE, Carr SA, Roberts GD, Caradonna SJ. Ladner RD, et al. J Biol Chem. 1996 Mar 29;271(13):7745-51. doi: 10.1074/jbc.271.13.7745. J Biol Chem. 1996. PMID: 8631816
Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase.
Ladner RD, Carr SA, Huddleston MJ, McNulty DE, Caradonna SJ. Ladner RD, et al. J Biol Chem. 1996 Mar 29;271(13):7752-7. doi: 10.1074/jbc.271.13.7752. J Biol Chem. 1996. PMID: 8631817
In the preceding report (Ladner, R.D., McNulty, D.E., Carr, S.A., Roberts, G.D., and Caradonna, S.J. (1996) J. Biol. Chem. 271, 7745-7751), we identified two distinct isoforms of dUTPase in human cells. ...
In the preceding report (Ladner, R.D., McNulty, D.E., Carr, S.A., Roberts, G.D., and Caradonna, S.J. (1996) J. Biol. Chem. 271, 7745- …
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