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ST101 induces a novel 17 kDa APP cleavage that precludes Aβ generation in vivo.
Green KN, Khashwji H, Estrada T, Laferla FM. Green KN, et al. Ann Neurol. 2011 May;69(5):831-44. doi: 10.1002/ana.22325. Epub 2011 Mar 17. Ann Neurol. 2011. PMID: 21416488
Injury induces presenilin-1 gene expression in mouse brain.
Cribbs DH, Chen LS, Cotman CW, LaFerla FM. Cribbs DH, et al. Neuroreport. 1996 Jul 29;7(11):1773-6. doi: 10.1097/00001756-199607290-00016. Neuroreport. 1996. PMID: 8905662
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.
Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. Leissring MA, et al. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4697-702. doi: 10.1073/pnas.072033799. Epub 2002 Mar 26. Proc Natl Acad Sci U S A. 2002. PMID: 11917117 Free PMC article.
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. Sugarman MC, et al. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6334-9. doi: 10.1073/pnas.082545599. Epub 2002 Apr 23. Proc Natl Acad Sci U S A. 2002. PMID: 11972038 Free PMC article.
Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.
LaFerla FM. LaFerla FM. Nat Rev Neurosci. 2002 Nov;3(11):862-72. doi: 10.1038/nrn960. Nat Rev Neurosci. 2002. PMID: 12415294 Review. No abstract available.
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Oddo S, et al. Neuron. 2003 Jul 31;39(3):409-21. doi: 10.1016/s0896-6273(03)00434-3. Neuron. 2003. PMID: 12895417
Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.
Stutzmann GE, Caccamo A, LaFerla FM, Parker I. Stutzmann GE, et al. J Neurosci. 2004 Jan 14;24(2):508-13. doi: 10.1523/JNEUROSCI.4386-03.2004. J Neurosci. 2004. PMID: 14724250 Free PMC article.
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