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Phosphoinositide 3-kinase signalling--which way to target?
Wymann MP, Zvelebil M, Laffargue M. Wymann MP, et al. Among authors: laffargue m. Trends Pharmacol Sci. 2003 Jul;24(7):366-76. doi: 10.1016/S0165-6147(03)00163-9. Trends Pharmacol Sci. 2003. PMID: 12871670 Review. No abstract available.
PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.
Walser R, Burke JE, Gogvadze E, Bohnacker T, Zhang X, Hess D, Küenzi P, Leitges M, Hirsch E, Williams RL, Laffargue M, Wymann MP. Walser R, et al. Among authors: laffargue m. PLoS Biol. 2013;11(6):e1001587. doi: 10.1371/journal.pbio.1001587. Epub 2013 Jun 25. PLoS Biol. 2013. PMID: 23824069 Free PMC article.
Resistance to thromboembolism in PI3Kgamma-deficient mice.
Hirsch E, Bosco O, Tropel P, Laffargue M, Calvez R, Altruda F, Wymann M, Montrucchio G. Hirsch E, et al. Among authors: laffargue m. FASEB J. 2001 Sep;15(11):2019-21. doi: 10.1096/fj.00-0810fje. Epub 2001 Jul 9. FASEB J. 2001. PMID: 11511514
Tumour biology. Weakening link to colorectal cancer?
Barbier M, Attoub S, Calvez R, Laffargue M, Jarry A, Mareel M, Altruda F, Gespach C, Wu D, Lu B, Hirsch E, Wymann MP. Barbier M, et al. Among authors: laffargue m. Nature. 2001 Oct 25;413(6858):796. doi: 10.1038/35101660. Nature. 2001. PMID: 11677595 No abstract available.
Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy.
Wymann MP, Björklöf K, Calvez R, Finan P, Thomast M, Trifilieff A, Barbier M, Altruda F, Hirsch E, Laffargue M. Wymann MP, et al. Among authors: laffargue m. Biochem Soc Trans. 2003 Feb;31(Pt 1):275-80. doi: 10.1042/bst0310275. Biochem Soc Trans. 2003. PMID: 12546701 Review.
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.
Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M. Smirnova NF, et al. Among authors: laffargue m. J Exp Med. 2014 Aug 25;211(9):1779-92. doi: 10.1084/jem.20131276. Epub 2014 Jul 29. J Exp Med. 2014. PMID: 25073791 Free PMC article.
61 results