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Hypocapnia and the injured brain: more harm than benefit.
Curley G, Kavanagh BP, Laffey JG. Curley G, et al. Among authors: laffey jg. Crit Care Med. 2010 May;38(5):1348-59. doi: 10.1097/CCM.0b013e3181d8cf2b. Crit Care Med. 2010. PMID: 20228681 Review.
Carbon dioxide and the critically ill--too little of a good thing?
Laffey JG, Kavanagh BP. Laffey JG, et al. Lancet. 1999 Oct 9;354(9186):1283-6. doi: 10.1016/S0140-6736(99)02388-0. Lancet. 1999. PMID: 10520649 Review.
Buffering hypercapnic acidosis worsens acute lung injury.
Laffey JG, Engelberts D, Kavanagh BP. Laffey JG, et al. Am J Respir Crit Care Med. 2000 Jan;161(1):141-6. doi: 10.1164/ajrccm.161.1.9905080. Am J Respir Crit Care Med. 2000. PMID: 10619811
Biological effects of hypercapnia.
Laffey JG, Kavanagh BP. Laffey JG, et al. Intensive Care Med. 2000 Jan;26(1):133-8. doi: 10.1007/s001340050027. Intensive Care Med. 2000. PMID: 10663296 No abstract available.
Adverse ventilatory strategy causes pulmonary-to-systemic translocation of endotoxin.
Murphy DB, Cregg N, Tremblay L, Engelberts D, Laffey JG, Slutsky AS, Romaschin A, Kavanagh BP. Murphy DB, et al. Among authors: laffey jg. Am J Respir Crit Care Med. 2000 Jul;162(1):27-33. doi: 10.1164/ajrccm.162.1.9908110. Am J Respir Crit Care Med. 2000. PMID: 10903215
Injurious effects of hypocapnic alkalosis in the isolated lung.
Laffey JG, Engelberts D, Kavanagh BP. Laffey JG, et al. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):399-405. doi: 10.1164/ajrccm.162.2.9911026. Am J Respir Crit Care Med. 2000. PMID: 10934060
Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion.
Laffey JG, Tanaka M, Engelberts D, Luo X, Yuan S, Tanswell AK, Post M, Lindsay T, Kavanagh BP. Laffey JG, et al. Am J Respir Crit Care Med. 2000 Dec;162(6):2287-94. doi: 10.1164/ajrccm.162.6.2003066. Am J Respir Crit Care Med. 2000. PMID: 11112153
Hypocapnia.
Laffey JG, Kavanagh BP. Laffey JG, et al. N Engl J Med. 2002 Jul 4;347(1):43-53. doi: 10.1056/NEJMra012457. N Engl J Med. 2002. PMID: 12097540 Review. No abstract available.
Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism.
Loughrey JP, Laffey JG, Moore BJ, Lynch F, Boylan JF, McLoughlin P. Loughrey JP, et al. Among authors: laffey jg. Crit Care Med. 2003 Mar;31(3):910-5. doi: 10.1097/01.CCM.0000053516.15727.E5. Crit Care Med. 2003. PMID: 12627004
Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.
Laffey JG, Honan D, Hopkins N, Hyvelin JM, Boylan JF, McLoughlin P. Laffey JG, et al. Am J Respir Crit Care Med. 2004 Jan 1;169(1):46-56. doi: 10.1164/rccm.200205-394OC. Epub 2003 Sep 4. Am J Respir Crit Care Med. 2004. PMID: 12958048
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