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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1993 1
1994 2
1995 3
1996 1
1997 1
1998 3
1999 3
2000 2
2001 4
2002 5
2003 12
2004 4
2005 7
2006 8
2007 8
2008 7
2009 6
2010 11
2011 5
2012 6
2013 3
2014 4
2015 3
2016 5
2017 6
2018 1
2020 1
2021 3
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119 results
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[Pharmacological and therapeutic properties of lafutidine (stogar and protecadin), a novel histamine H2 receptor antagonist with gastroprotective activity].
Tanaka M, Banba M, Joko A, Moriyama Y. Tanaka M, et al. Nihon Yakurigaku Zasshi. 2001 Jun;117(6):377-86. doi: 10.1254/fpj.117.377. Nihon Yakurigaku Zasshi. 2001. PMID: 11436515 Review. Japanese.
Lafutidine exhibited potent and long-lasting H2 antagonism and prolonged antisecretion. ...Furthermore, effectiveness of lafutidine against NSAIDs-induced ulcer was high. From these results, lafutidine is equal or superior to conventional H2 antagonists in an
Lafutidine exhibited potent and long-lasting H2 antagonism and prolonged antisecretion. ...Furthermore, effectiveness of lafutidin
Lafutidine, a histamine H2 receptor antagonist with mucosal protective properties, attenuates 5-fluorouracil-induced intestinal mucositis in mice through activation of extrinsic primary afferent neurons.
Sano T, Utsumi D, Amagase K, Matsumoto K, Tominaga M, Higuchi K, Takeuchi T, Kato S. Sano T, et al. J Physiol Pharmacol. 2017 Feb;68(1):79-90. J Physiol Pharmacol. 2017. PMID: 28456772 Free article.
The preventive effects of lafutidine were completely abolished in sensory deafferented and TRPV1-KO mice. ...Lafutidine induced Alcian Blue and PAS-positive mucus production in the small intestine. ...
The preventive effects of lafutidine were completely abolished in sensory deafferented and TRPV1-KO mice. ...Lafutidine induce …
Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study.
Kato M, Kamada G, Yamamoto K, Nishida U, Imai A, Yoshida T, Ono S, Nakagawa M, Nakagawa S, Shimizu Y, Asaka M. Kato M, et al. J Gastroenterol Hepatol. 2010 Oct;25(10):1631-5. doi: 10.1111/j.1440-1746.2010.06375.x. J Gastroenterol Hepatol. 2010. PMID: 20880171 Clinical Trial.
Both groups received 81 mg of aspirin once daily for 14 days (on days 1 to 14) and 60 mg of loxoprofen three times daily for the last 7 days (on days 8 to 14). Placebo or 10 mg of lafutidine was administered twice daily for 14 days in each group. After a 2-week washout per …
Both groups received 81 mg of aspirin once daily for 14 days (on days 1 to 14) and 60 mg of loxoprofen three times daily for the last 7 days …
Lafutidine-induced increase in intracellular ca(2+) concentrations in PC12 and endothelial cells.
Kunieda K, Someya A, Horie S, Ajioka H, Murayama T. Kunieda K, et al. J Pharmacol Sci. 2005 Jan;97(1):67-74. doi: 10.1254/jphs.fpj04042x. Epub 2005 Jan 15. J Pharmacol Sci. 2005. PMID: 15655292 Free article.
Since the effect of lafutidine on the intracellular Ca(2+) concentration ([Ca(2+)](i)) in cells has not been elucidated, we investigated the lafutidine response to [Ca(2+)](i) in rat pheochromocytoma PC12 and human endothelial cells. ...In endothelial cells, lafu
Since the effect of lafutidine on the intracellular Ca(2+) concentration ([Ca(2+)](i)) in cells has not been elucidated, we investiga …
Lafutidine increases hepatic blood flow via potentiating the action of central thyrotropin-releasing hormone in rats.
Yoneda M, Kurosawa M, Watanobe H, Terano A. Yoneda M, et al. J Gastroenterol Hepatol. 2003 Feb;18(2):177-84. doi: 10.1046/j.1440-1746.2003.02933.x. J Gastroenterol Hepatol. 2003. PMID: 12542603
RESULTS: Intracisternal injection of RX 77368 (1.5 ng) or intraportal lafutidine (10 mg/kg) by itself did not affect hepatic blood flow, but co-injection of intracisternal RX 77368 (1.5 ng) and intraportal lafutidine (5 mg/kg) increased it with peak response at 30 m …
RESULTS: Intracisternal injection of RX 77368 (1.5 ng) or intraportal lafutidine (10 mg/kg) by itself did not affect hepatic blood fl …
Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease.
Takenaka R, Okada H, Kawano S, Komazawa Y, Yoshinaga F, Nagata S, Inoue M, Komatsu H, Onogawa S, Kushiyama Y, Mukai S, Todo H, Okanobu H, Manabe N, Tanaka S, Haruma K, Kinoshita Y. Takenaka R, et al. World J Gastroenterol. 2016 Jun 21;22(23):5430-5. doi: 10.3748/wjg.v22.i23.5430. World J Gastroenterol. 2016. PMID: 27340360 Free PMC article. Clinical Trial.
AIM: To compare the clinical efficacy of the second-generation H2RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease (GERD). ...CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, e …
AIM: To compare the clinical efficacy of the second-generation H2RA lafutidine with that of lansoprazole in Japanese patients with mi …
Lafutidine inhibits Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells.
Nozawa Y, Nishihara K, Akizawa Y, Orimoto N, Nakano M, Uji T, Ajioka H, Kanda A, Matsuura N, Kiniwa M. Nozawa Y, et al. J Gastroenterol Hepatol. 2004 May;19(5):506-11. doi: 10.1111/j.1440-1746.2003.03330.x. J Gastroenterol Hepatol. 2004. PMID: 15086593
Lafutidine also significantly inhibited H. pylori-induced IL-6 release. Both TNF-alpha and IL-1beta-induced IL-8 releases, conversely, were little affected by lafutidine up to a concentration of 10(-5) M. CONCLUSIONS: These results suggest that lafutidine inh
Lafutidine also significantly inhibited H. pylori-induced IL-6 release. Both TNF-alpha and IL-1beta-induced IL-8 releases, conversely
Lafutidine changes levels of somatostatin, calcitonin gene-related peptide, and secretin in human plasma.
Itoh H, Naito T, Takeyama M. Itoh H, et al. Biol Pharm Bull. 2002 Mar;25(3):379-82. doi: 10.1248/bpb.25.379. Biol Pharm Bull. 2002. PMID: 11913538 Free article.
After a single oral administration of lafutidine (10 mg), the plasma lafutidine level (186 +/- 13.4ng/ml) was highest in the 60-min sample after administration and then the plasma level fell. Lafutidine caused significant increase in plasma somatostatin level …
After a single oral administration of lafutidine (10 mg), the plasma lafutidine level (186 +/- 13.4ng/ml) was highest in the 6 …
Lafutidine facilitates calcitonin gene-related peptide (CGRP) nerve-mediated vasodilation via vanilloid-1 receptors in rat mesenteric resistance arteries.
Sugiyama T, Hatanaka Y, Iwatani Y, Jin X, Kawasaki H. Sugiyama T, et al. J Pharmacol Sci. 2008 Mar;106(3):505-11. doi: 10.1254/jphs.fp0072259. Epub 2008 Mar 12. J Pharmacol Sci. 2008. PMID: 18344609 Free article.
Lafutidine is a histamine H(2)-receptor antagonist with gastric antisecretory and gastroprotective activity associated with activation of capsaicin-sensitive nerves. ...The decreased PNS-induced vasodilation by ruthenium red or capsazepine was not affected by perfusion of
Lafutidine is a histamine H(2)-receptor antagonist with gastric antisecretory and gastroprotective activity associated with activatio
Lafutidine, a unique histamine H2-receptor antagonist, inhibits distention-induced gastric acid secretion through an H2 receptor-independent mechanism.
Nakano M, Kitano S, Nanri M, Kiniwa M. Nakano M, et al. Eur J Pharmacol. 2011 May 11;658(2-3):236-41. doi: 10.1016/j.ejphar.2011.02.007. Epub 2011 Feb 22. Eur J Pharmacol. 2011. PMID: 21349265
Moreover, gastric acid secretion induced by the intravenous perfusion of carbachol into SD rats was strongly inhibited by lafutidine but only partially inhibited by famotidine. The antisecretory action of lafutidine under these conditions was partly reversed by the …
Moreover, gastric acid secretion induced by the intravenous perfusion of carbachol into SD rats was strongly inhibited by lafutidine
119 results