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Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism.
Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ. Lagor WR, et al. Methods Mol Biol. 2013;1027:273-307. doi: 10.1007/978-1-60327-369-5_13. Methods Mol Biol. 2013. PMID: 23912992
Gene Delivery in Lipid Research and Therapies.
De Giorgi M, Lagor WR. De Giorgi M, et al. Among authors: lagor wr. Methodist Debakey Cardiovasc J. 2019 Jan-Mar;15(1):62-69. doi: 10.14797/mdcj-15-1-62. Methodist Debakey Cardiovasc J. 2019. PMID: 31049151 Free PMC article. Review.
Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy.
Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WR. Palmer EE, et al. Among authors: lagor wr. Hum Mol Genet. 2016 Jul 15;25(14):3042-3054. doi: 10.1093/hmg/ddw157. Epub 2016 Jun 6. Hum Mol Genet. 2016. PMID: 27270415 Free PMC article.
Targeting adipose tissue via systemic gene therapy.
O'Neill SM, Hinkle C, Chen SJ, Sandhu A, Hovhannisyan R, Stephan S, Lagor WR, Ahima RS, Johnston JC, Reilly MP. O'Neill SM, et al. Among authors: lagor wr. Gene Ther. 2014 Jul;21(7):653-61. doi: 10.1038/gt.2014.38. Epub 2014 May 15. Gene Ther. 2014. PMID: 24830434 Free PMC article.
Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia.
Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ. Kassim SH, et al. Among authors: lagor w. Hum Gene Ther. 2013 Jan;24(1):19-26. doi: 10.1089/hum.2012.108. Epub 2012 Nov 14. Hum Gene Ther. 2013. PMID: 22985273 Free PMC article.
Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport.
Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ. Kuwano T, et al. Among authors: lagor wr. J Lipid Res. 2017 Apr;58(4):731-741. doi: 10.1194/jlr.M074625. Epub 2017 Jan 30. J Lipid Res. 2017. PMID: 28137768 Free PMC article.
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.
Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Bissig-Choisat B, et al. Among authors: lagor wr. Nat Commun. 2015 Jun 17;6:7339. doi: 10.1038/ncomms8339. Nat Commun. 2015. PMID: 26081744 Free PMC article.
Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.
Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ. Brown RJ, et al. Among authors: lagor wr. Circ Res. 2010 Aug 6;107(3):357-64. doi: 10.1161/CIRCRESAHA.110.219188. Epub 2010 Jun 17. Circ Res. 2010. PMID: 20558822 Free PMC article.
Phospholipidation of HDL--how much is too much?
Lagor WR, Rader DJ. Lagor WR, et al. Clin Chem. 2011 Jan;57(1):4-6. doi: 10.1373/clinchem.2010.156224. Epub 2010 Nov 15. Clin Chem. 2011. PMID: 21078838 No abstract available.
Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo.
Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ. Lagor WR, et al. Arterioscler Thromb Vasc Biol. 2009 Jan;29(1):40-6. doi: 10.1161/ATVBAHA.108.177105. Epub 2008 Nov 13. Arterioscler Thromb Vasc Biol. 2009. PMID: 19008531 Free PMC article.
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