Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Text availability
Article attribute
Article type
Publication date

Search Results

79 results
Filters applied: . Clear all Results are displayed in a computed author sort order. Results by year timeline is unavailable
Page 1
Computer-aided prediction of QT-prolongation.
Filz O, Lagunin A, Filimonov D, Poroikov V. Filz O, et al. Among authors: lagunin a. SAR QSAR Environ Res. 2008 Jan-Mar;19(1-2):81-90. doi: 10.1080/10629360701844183. SAR QSAR Environ Res. 2008. PMID: 18311636
Drug-induced cardiac arrhythmia is acknowledged as a serious obstacle in successful development of new drugs. Several methods for in silico prediction of acquired long QT syndrome (LQTS) caused by the pharmacological blockade of human hERG K+ channels are discussed in lite …
Drug-induced cardiac arrhythmia is acknowledged as a serious obstacle in successful development of new drugs. Several methods for in …
PASS: prediction of activity spectra for biologically active substances.
Lagunin A, Stepanchikova A, Filimonov D, Poroikov V. Lagunin A, et al. Bioinformatics. 2000 Aug;16(8):747-8. doi: 10.1093/bioinformatics/16.8.747. Bioinformatics. 2000. PMID: 11099264
The PASS (prediction of activity spectra for substances) software product, which predicts more than 300 pharmacological effects and biochemical mechanisms on the basis of the structural formula of a substance, may be efficiently used to find new targets (mechanisms) for so …
The PASS (prediction of activity spectra for substances) software product, which predicts more than 300 pharmacological effects and biochemi …
Robustness of biological activity spectra predicting by computer program PASS for noncongeneric sets of chemical compounds.
Poroikov VV, Filimonov DA, Borodina YV, Lagunin AA, Kos A. Poroikov VV, et al. Among authors: lagunin aa. J Chem Inf Comput Sci. 2000 Nov-Dec;40(6):1349-55. doi: 10.1021/ci000383k. J Chem Inf Comput Sci. 2000. PMID: 11128093
In this paper we investigate the influence on the accuracy of predicting the types of activity with PASS by (a) reduction of the number of structures in the training set and (b) reduction of the number of known activities in the training set. ...
In this paper we investigate the influence on the accuracy of predicting the types of activity with PASS by (a) reduction of the numb …
Computer aided prediction of biological activity spectra: evaluating versus known and predicting of new activities for thiazole derivatives.
Geronikaki A, Lagunin A, Poroikov V, Filimonov D, Hadjipavlou-Litina D, Vicini P. Geronikaki A, et al. Among authors: lagunin a. SAR QSAR Environ Res. 2002 May-Jun;13(3-4):457-71. doi: 10.1080/10629360290014322. SAR QSAR Environ Res. 2002. PMID: 12184387
Computer aided prediction of biological activity spectra by the computer program PASS was applied to a set of 89 new thiazole derivatives. ...Therefore, computer aided prediction using the Prediction of Activity Spectra for Substances (PASS) system (http://www.ibmh.msk.su/ …
Computer aided prediction of biological activity spectra by the computer program PASS was applied to a set of 89 new thiazole derivat …
PASS biological activity spectrum predictions in the enhanced open NCI database browser.
Poroikov VV, Filimonov DA, Ihlenfeldt WD, Gloriozova TA, Lagunin AA, Borodina YV, Stepanchikova AV, Nicklaus MC. Poroikov VV, et al. Among authors: lagunin aa. J Chem Inf Comput Sci. 2003 Jan-Feb;43(1):228-36. doi: 10.1021/ci020048r. J Chem Inf Comput Sci. 2003. PMID: 12546557
A total of 565 different types of activity are included, encompassing general pharmacological effects, specific mechanisms of action, known toxicities, and others. Application of this Web-based service to prediction of activities of the kinds "Angiogenesis inhibitor," "Ant
A total of 565 different types of activity are included, encompassing general pharmacological effects, specific mechanisms of action,
Prediction of biological activity spectra for substances: evaluation on the diverse sets of drug-like structures.
Stepanchikova AV, Lagunin AA, Filimonov DA, Poroikov VV. Stepanchikova AV, et al. Among authors: lagunin aa. Curr Med Chem. 2003 Feb;10(3):225-33. doi: 10.2174/0929867033368510. Curr Med Chem. 2003. PMID: 12570709 Review.
The concept of Biological Activity Spectrum served as a basis for developing PASS (Prediction of Activity Spectra for Substances) software product. ...A web-site with a new internet version of PASS is introduced into practice in December 2001 (http://www.ibmh …
The concept of Biological Activity Spectrum served as a basis for developing PASS (Prediction of Activity Spectra for Substances) sof …
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.
Lagunin AA, Gomazkov OA, Filimonov DA, Gureeva TA, Dilakyan EA, Kugaevskaya EV, Elisseeva YE, Solovyeva NI, Poroikov VV. Lagunin AA, et al. J Med Chem. 2003 Jul 17;46(15):3326-32. doi: 10.1021/jm021089h. J Med Chem. 2003. PMID: 12852763
At a later time, all these compounds were found to be the inhibitors of both ACE and NEP. The most potent compounds had IC(50) of 10(-7)-10(-9) M for ACE and 10(-5) M for NEP. ...
At a later time, all these compounds were found to be the inhibitors of both ACE and NEP. The most potent compounds had IC(50) of 10( …
Prediction of biological activity spectra via the Internet.
Sadym A, Lagunin A, Filimonov D, Poroikov V. Sadym A, et al. Among authors: lagunin a. SAR QSAR Environ Res. 2003 Oct-Dec;14(5-6):339-47. doi: 10.1080/10629360310001623935. SAR QSAR Environ Res. 2003. PMID: 14758978 Review.
Based on a structural formulae of compounds presented as SDF or MOL-files, computer program PASS predicts 900 pharmacological effects, mechanism of action, and specific toxicity. ...
Based on a structural formulae of compounds presented as SDF or MOL-files, computer program PASS predicts 900 pharmacological effects …
Study of local anesthetic activity of some derivatives of 3-amino-benzo-[d]-isothiazole.
Geronikaki A, Vicini P, Theophilidis G, Lagunin A, Poroikov V, Dearden JC. Geronikaki A, et al. Among authors: lagunin a. SAR QSAR Environ Res. 2003 Oct-Dec;14(5-6):485-95. doi: 10.1080/10629360310001624051. SAR QSAR Environ Res. 2003. PMID: 14758990
The results show that the tested compounds can be divided into three groups: (a) compounds with action similar to lidocaine, (b) compounds with action lower than lidocaine and (c) compounds which block completely the evoked CAP, but after the compound was removed and repla …
The results show that the tested compounds can be divided into three groups: (a) compounds with action similar to lidocaine, (b) comp …
Computer-aided rodent carcinogenicity prediction.
Lagunin AA, Dearden JC, Filimonov DA, Poroikov VV. Lagunin AA, et al. Mutat Res. 2005 Oct 3;586(2):138-46. doi: 10.1016/j.mrgentox.2005.06.005. Mutat Res. 2005. PMID: 16112600
79 results
Jump to page
Feedback