Lai Y - Search Results

1

Improved extrapolation of hepatobiliary clearance from in vitro sandwich cultured rat hepatocytes through absolute quantification of hepatobiliary transporters.

Li N, Singh P, Mandrell KM, Lai Y. Li N, et al. Among authors: lai y. Mol Pharm. 2010 Jun 7;7(3):630-41. doi: 10.1021/mp9001574. Mol Pharm. 2010. PMID: 20438085

2

Structure-activity relationships for interaction with multidrug resistance protein 2 (ABCC2/MRP2): the role of torsion angle for a series of biphenyl-substituted heterocycles.

Lai Y, Xing L, Poda GI, Hu Y. Lai Y, et al. Drug Metab Dispos. 2007 Jun;35(6):937-45. doi: 10.1124/dmd.106.013250. Epub 2007 Mar 19. Drug Metab Dispos. 2007. PMID: 17371800

3

Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry.

Li N, Nemirovskiy OV, Zhang Y, Yuan H, Mo J, Ji C, Zhang B, Brayman TG, Lepsy C, Heath TG, Lai Y. Li N, et al. Among authors: lai y. Anal Biochem. 2008 Sep 15;380(2):211-22. doi: 10.1016/j.ab.2008.05.032. Epub 2008 May 27. Anal Biochem. 2008. PMID: 18558078

4

Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human.

Li M, Yuan H, Li N, Song G, Zheng Y, Baratta M, Hua F, Thurston A, Wang J, Lai Y. Li M, et al. Among authors: lai y. Eur J Pharm Sci. 2008 Sep 2;35(1-2):114-26. doi: 10.1016/j.ejps.2008.06.008. Epub 2008 Jun 28. Eur J Pharm Sci. 2008. PMID: 18639632

5

Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.

Li N, Zhang Y, Hua F, Lai Y. Li N, et al. Among authors: lai y. Drug Metab Dispos. 2009 Jan;37(1):66-73. doi: 10.1124/dmd.108.023234. Epub 2008 Oct 2. Drug Metab Dispos. 2009. PMID: 18832477

6

Saturation of multidrug-resistant protein 2 (mrp2/abcc2)-mediated hepatobiliary secretion: nonlinear pharmacokinetics of a heterocyclic compound in rats after intravenous bolus administration.

Hu Y, Sampson KE, Heyde BR, Mandrell KM, Li N, Zutshi A, Lai Y. Hu Y, et al. Among authors: lai y. Drug Metab Dispos. 2009 Apr;37(4):841-6. doi: 10.1124/dmd.108.024059. Epub 2009 Jan 12. Drug Metab Dispos. 2009. PMID: 19139164

7

LC-MS/MS mediated absolute quantification and comparison of bile salt export pump and breast cancer resistance protein in livers and hepatocytes across species.

Li N, Palandra J, Nemirovskiy OV, Lai Y. Li N, et al. Among authors: lai y. Anal Chem. 2009 Mar 15;81(6):2251-9. doi: 10.1021/ac8024009. Anal Chem. 2009. PMID: 19209887

8

Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs.

Yuan H, Li N, Lai Y. Yuan H, et al. Among authors: lai y. Drug Metab Dispos. 2009 Jul;37(7):1443-7. doi: 10.1124/dmd.108.026245. Epub 2009 Apr 16. Drug Metab Dispos. 2009. PMID: 19372225

9

Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.

Li N, Bi YA, Duignan DB, Lai Y. Li N, et al. Among authors: lai y. Mol Pharm. 2009 Jul-Aug;6(4):1180-9. doi: 10.1021/mp900044x. Mol Pharm. 2009. PMID: 19545175

10

Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.

Lai Y. Lai Y. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1175-87. doi: 10.1517/17425250903127234. Expert Opin Drug Metab Toxicol. 2009. PMID: 19611403 Review.

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