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A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial.
Laitinen LA, Laitinen A, Haahtela T. Laitinen LA, et al. J Allergy Clin Immunol. 1992 Jul;90(1):32-42. doi: 10.1016/s0091-6749(06)80008-4. J Allergy Clin Immunol. 1992. PMID: 1629507 Clinical Trial.
The study was conducted as a randomized, double-blind, parallel-group trial. Seven patients inhaled 600 micrograms, twice daily, of budesonide, the other seven patients inhaled 375 micrograms, twice daily, of terbutaline via identical metered-dose inhalers with a sp …
The study was conducted as a randomized, double-blind, parallel-group trial. Seven patients inhaled 600 micrograms, twice daily, of b …
Leukotriene E(4)-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma.
Laitinen A, Lindqvist A, Halme M, Altraja A, Laitinen LA. Laitinen A, et al. J Allergy Clin Immunol. 2005 Feb;115(2):259-65. doi: 10.1016/j.jaci.2004.10.021. J Allergy Clin Immunol. 2005. PMID: 15696079 Clinical Trial.
METHODS: Bronchial biopsies were taken and pulmonary function was measured before and 4 to 6 hours after the dose of inhaled LTE 4 causing a > or =15% fall in FEV 1 at baseline both at week 0 and after 6-week randomly assigned treatment with a high dose of zafirl …
METHODS: Bronchial biopsies were taken and pulmonary function was measured before and 4 to 6 hours after the dose of inhaled LTE 4 causing …
Salmeterol resolves airway obstruction but does not possess anti-eosinophil efficacy in newly diagnosed asthma: a randomized, double-blind, parallel group biopsy study comparing the effects of salmeterol, fluticasone propionate, and disodium cromoglycate.
Lindqvist A, Karjalainen EM, Laitinen LA, Kava T, Altraja A, Pulkkinen M, Halme M, Laitinen A. Lindqvist A, et al. J Allergy Clin Immunol. 2003 Jul;112(1):23-8. doi: 10.1067/mai.2003.1500. J Allergy Clin Immunol. 2003. PMID: 12847475 Clinical Trial.
BACKGROUND: Salmeterol (SLM) is a long-acting beta(2)-receptor agonist that produces bronchodilatation for 12 hours in asthmatic subjects. ...
BACKGROUND: Salmeterol (SLM) is a long-acting beta(2)-receptor agonist that produces bronchodilatation for 12 hours in asthmatic subj …
Airway morphology: epithelium/basement membrane.
Laitinen A, Laitinen LA. Laitinen A, et al. Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 2):S14-7. doi: 10.1164/ajrccm/150.5_Pt_2.S14. Am J Respir Crit Care Med. 1994. PMID: 7952583 Review.
Recent biopsy studies have revealed that in asthma an airway inflammatory process is present even at a clinically early stage of the disease. ...Perhaps a more important aspect than epithelial shedding is a more continuous replacement of the ciliated epitheli …
Recent biopsy studies have revealed that in asthma an airway inflammatory process is present even at a clinically early stage of the …
Lymphoid aggregates in endobronchial biopsies from young elite cross-country skiers.
Sue-Chu M, Karjalainen EM, Altraja A, Laitinen A, Laitinen LA, Naess AB, Larsson L, Bjermer L. Sue-Chu M, et al. Am J Respir Crit Care Med. 1998 Aug;158(2):597-601. doi: 10.1164/ajrccm.158.2.9711012. Am J Respir Crit Care Med. 1998. PMID: 9700140
The skiers had a prevalence of respiratory allergy (18%), asthma-like symptoms (59%), beta2 agonist medication (25%), and methacholine bronchial hyperresponsiveness (79%). ...The aggregates were not associated with a history of respiratory allergy or asthma-like sym …
The skiers had a prevalence of respiratory allergy (18%), asthma-like symptoms (59%), beta2 agonist medication (25%), and methacholin …
Placebo-controlled study of inhaled budesonide on indices of airway inflammation in bronchoalveolar lavage fluid and bronchial biopsies in cross-country skiers.
Sue-Chu M, Karjalainen EM, Laitinen A, Larsson L, Laitinen LA, Bjermer L. Sue-Chu M, et al. Respiration. 2000;67(4):417-25. doi: 10.1159/000029541. Respiration. 2000. PMID: 10940797 Clinical Trial.
METHODS: A randomised double-blind placebo-controlled parallel-group bronchial biopsy and bronchoalveolar lavage (BAL) study of 25 (19 male) competitive cross-country skiers (mean age 18 (16-20) years for a mean (range) treatment period of 22 (10-32) weeks over the …
METHODS: A randomised double-blind placebo-controlled parallel-group bronchial biopsy and bronchoalveolar lavage (BAL) study of 25 (1 …
Cellular infiltrates in asthma and in chronic obstructive pulmonary disease.
Laitinen A, Laitinen LA. Laitinen A, et al. Am Rev Respir Dis. 1991 May;143(5 Pt 1):1159-60; discussion 1161. doi: 10.1164/ajrccm/143.5_Pt_1.1159. Am Rev Respir Dis. 1991. PMID: 2024828 Review. No abstract available.
Eosinophilic airway inflammation during exacerbation of asthma and its treatment with inhaled corticosteroid.
Laitinen LA, Laitinen A, Heino M, Haahtela T. Laitinen LA, et al. Am Rev Respir Dis. 1991 Feb;143(2):423-7. doi: 10.1164/ajrccm/143.2.423. Am Rev Respir Dis. 1991. PMID: 1990962
A striking increase in the number of bronchial epithelial eosinophils was associated with an increase in both airway hyperresponsiveness and asthma symptoms. ...This was accompanied by an improvement in the ultrastructure of bronchial mucosa and a decrease in the nu
A striking increase in the number of bronchial epithelial eosinophils was associated with an increase in both airway hyperresponsiven
Vascular beds in the airways of normal subjects and asthmatics.
Laitinen A, Laitinen LA. Laitinen A, et al. Eur Respir J Suppl. 1990 Dec;12:658s-661s; discussion 661s-662s. Eur Respir J Suppl. 1990. PMID: 2076160 Review.
In humans a rich network of capillaries runs subepithelially from the central airways to the level of the peripheral bronchioles, where it anastomoses with the alveolar capillaries. The tracheobronchial capillaries converge to form venules extending to a deeper plex …
In humans a rich network of capillaries runs subepithelially from the central airways to the level of the peripheral bronchioles, whe …
Bronchial biopsies in drug intervention studies in CB and COAD.
Laitinen A, Laitinen LA, Haahtela T. Laitinen A, et al. Agents Actions Suppl. 1990;30:173-81. doi: 10.1007/978-3-0348-7488-5_13. Agents Actions Suppl. 1990. PMID: 2239528 Review.
Pathology studies may lead to a better understanding of basic pathophysiological mechanisms behind the diseases. The sequences of cellular events could be revealed so that morphology may be useful in intervention studies....
Pathology studies may lead to a better understanding of basic pathophysiological mechanisms behind the diseases. The sequences of cel …
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