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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis.
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Kapoor M, et al. Among authors: lajeunesse d. Nat Rev Rheumatol. 2011 Jan;7(1):33-42. doi: 10.1038/nrrheum.2010.196. Epub 2010 Nov 30. Nat Rev Rheumatol. 2011. PMID: 21119608 Review.
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.
Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M. Vasheghani F, et al. Among authors: lajeunesse d. Ann Rheum Dis. 2015 Mar;74(3):569-78. doi: 10.1136/annrheumdis-2014-205743. Epub 2015 Jan 8. Ann Rheum Dis. 2015. PMID: 25573665 Free PMC article.
Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium.
Pelletier JP, Kapoor M, Fahmi H, Lajeunesse D, Blesius A, Maillet J, Martel-Pelletier J. Pelletier JP, et al. Among authors: lajeunesse d. Ann Rheum Dis. 2013 Feb;72(2):250-7. doi: 10.1136/annrheumdis-2012-201710. Epub 2012 Oct 13. Ann Rheum Dis. 2013. PMID: 23065732
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis.
Kwan Tat S, Amiable N, Pelletier JP, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J. Kwan Tat S, et al. Among authors: lajeunesse d. Rheumatology (Oxford). 2009 Dec;48(12):1482-90. doi: 10.1093/rheumatology/kep300. Epub 2009 Sep 17. Rheumatology (Oxford). 2009. PMID: 19762475 Free PMC article.
New thoughts on the pathophysiology of osteoarthritis: one more step toward new therapeutic targets.
Martel-Pelletier J, Lajeunesse D, Fahmi H, Tardif G, Pelletier JP. Martel-Pelletier J, et al. Among authors: lajeunesse d. Curr Rheumatol Rep. 2006 Feb;8(1):30-6. doi: 10.1007/s11926-006-0022-6. Curr Rheumatol Rep. 2006. PMID: 16515762 Review.
Osteoarthritis: a metabolic disease induced by local abnormal leptin activity?
Lajeunesse D, Pelletier JP, Martel-Pelletier J. Lajeunesse D, et al. Curr Rheumatol Rep. 2005 Apr;7(2):79-81. doi: 10.1007/s11926-005-0057-0. Curr Rheumatol Rep. 2005. PMID: 15760585 Review. No abstract available.
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J. Pelletier JP, et al. Among authors: lajeunesse d. Arthritis Res Ther. 2005;7(5):R1091-102. doi: 10.1186/ar1788. Epub 2005 Jul 19. Arthritis Res Ther. 2005. PMID: 16207326 Free PMC article.
R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts.
Abed É, Chan TF, Delalandre A, Martel-Pelletier J, Pelletier JP, Lajeunesse D. Abed É, et al. Among authors: lajeunesse d. Arthritis Rheum. 2011 Dec;63(12):3865-75. doi: 10.1002/art.30625. Arthritis Rheum. 2011. PMID: 22127703
Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts.
Martineau X, Abed É, Martel-Pelletier J, Pelletier JP, Lajeunesse D. Martineau X, et al. Among authors: lajeunesse d. PLoS One. 2017 Aug 4;12(8):e0180711. doi: 10.1371/journal.pone.0180711. eCollection 2017. PLoS One. 2017. PMID: 28777797 Free PMC article.
Local leptin production in osteoarthritis subchondral osteoblasts may be responsible for their abnormal phenotypic expression.
Mutabaruka MS, Aoulad Aissa M, Delalandre A, Lavigne M, Lajeunesse D. Mutabaruka MS, et al. Among authors: lajeunesse d. Arthritis Res Ther. 2010;12(1):R20. doi: 10.1186/ar2925. Epub 2010 Feb 8. Arthritis Res Ther. 2010. PMID: 20141628 Free PMC article.
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