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Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy.
Lalvani A. Lalvani A. Chest. 2007 Jun;131(6):1898-906. doi: 10.1378/chest.06-2471. Chest. 2007. PMID: 17565023 Review.
A large and growing clinical evidence base indicates that both tests are more specific than the skin test because they are not confounded by prior BCG vaccination. ...
A large and growing clinical evidence base indicates that both tests are more specific than the skin test because they are not confou
Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis.
Guyot-Revol V, Innes JA, Hackforth S, Hinks T, Lalvani A. Guyot-Revol V, et al. Among authors: lalvani a. Am J Respir Crit Care Med. 2006 Apr 1;173(7):803-10. doi: 10.1164/rccm.200508-1294OC. Epub 2005 Dec 9. Am J Respir Crit Care Med. 2006. PMID: 16339919
MEASUREMENTS AND MAIN RESULTS: We detected a threefold increase in the frequency of CD4 + CD25(high) T cells (p<0.001) and a 2.2-fold increase in FoxP3 expression (p = 0.006) in patients with TB, and there was a positive correlation between these markers ( …
MEASUREMENTS AND MAIN RESULTS: We detected a threefold increase in the frequency of CD4 + CD25(high) T cells (p<0.001) and a
T cell-based tracking of multidrug resistant tuberculosis infection after brief exposure.
Richeldi L, Ewer K, Losi M, Bergamini BM, Roversi P, Deeks J, Fabbri LM, Lalvani A. Richeldi L, et al. Among authors: lalvani a. Am J Respir Crit Care Med. 2004 Aug 1;170(3):288-95. doi: 10.1164/rccm.200403-307OC. Epub 2004 May 6. Am J Respir Crit Care Med. 2004. PMID: 15130907 Clinical Trial.
We investigated M. tuberculosis transmission after brief exposure using a T cell-based assay, the enzyme-linked-immunospot (ELISPOT) for IFN-gamma. ...For each hour sharing room air with the index case, the odds of a positive ELISPOT result increased by 1.05 (95% CI …
We investigated M. tuberculosis transmission after brief exposure using a T cell-based assay, the enzyme-linked-immunospot (ELISPOT) …
Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count.
Dheda K, Lalvani A, Miller RF, Scott G, Booth H, Johnson MA, Zumla A, Rook GA. Dheda K, et al. Among authors: lalvani a. AIDS. 2005 Nov 18;19(17):2038-41. doi: 10.1097/01.aids.0000191923.08938.5b. AIDS. 2005. PMID: 16260914
Frequencies of region of difference 1 antigen-specific but not purified protein derivative-specific gamma interferon-secreting T cells correlate with the presence of tuberculosis disease but do not distinguish recent from remote latent infections.
Hinks TS, Dosanjh DP, Innes JA, Pasvol G, Hackforth S, Varia H, Millington KA, Liu XQ, Bakir M, Soysal A, Davidson RN, Gunatheesan R, Lalvani A. Hinks TS, et al. Among authors: lalvani a. Infect Immun. 2009 Dec;77(12):5486-95. doi: 10.1128/IAI.01436-08. Epub 2009 Sep 14. Infect Immun. 2009. PMID: 19752037 Free PMC article.
We compared the frequencies of gamma interferon (IFN-gamma)-secreting T cells specific for five region of difference 1 (RD1)-encoded antigens and one DosR-encoded antigen in 205 individuals either with active disease (n = 167), whose immune responses had failed to contain the bac …
We compared the frequencies of gamma interferon (IFN-gamma)-secreting T cells specific for five region of difference 1 (RD1)-encoded antigen …
Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact.
Bakir M, Millington KA, Soysal A, Deeks JJ, Efee S, Aslan Y, Dosanjh DP, Lalvani A. Bakir M, et al. Among authors: lalvani a. Ann Intern Med. 2008 Dec 2;149(11):777-87. doi: 10.7326/0003-4819-149-11-200812020-00248. Epub 2008 Oct 20. Ann Intern Med. 2008. PMID: 18936496 Free PMC article.
Of 381 contacts with positive ELISpot results, 11 developed active tuberculosis over 536 person-years of follow-up (incidence rate, 21 per 1000 person-years [95% CI, 10.2 to 36.7 per 1000 person-years]), a statistically significant 3- to 4-fold increased risk for progressi …
Of 381 contacts with positive ELISpot results, 11 developed active tuberculosis over 536 person-years of follow-up (incidence rate, 21 per 1 …
T-cell-based diagnosis of neonatal multidrug-resistant latent tuberculosis infection.
Richeldi L, Ewer K, Losi M, Bergamini BM, Millington K, Fabbri LM, Lalvani A. Richeldi L, et al. Among authors: lalvani a. Pediatrics. 2007 Jan;119(1):e1-5. doi: 10.1542/peds.2006-1057. Pediatrics. 2007. PMID: 17200234
Young children exposed to tuberculosis have a high risk of progression to severe tuberculosis disease, but diagnosis of recent infection is hindered by the poor sensitivity of the tuberculin skin test. ...We monitored a tuberculin skin test-negative infant whose mot …
Young children exposed to tuberculosis have a high risk of progression to severe tuberculosis disease, but diagnosis of recent infect …
Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection.
Shams H, Weis SE, Klucar P, Lalvani A, Moonan PK, Pogoda JM, Ewer K, Barnes PF. Shams H, et al. Among authors: lalvani a. Am J Respir Crit Care Med. 2005 Nov 1;172(9):1161-8. doi: 10.1164/rccm.200505-748OC. Epub 2005 Aug 4. Am J Respir Crit Care Med. 2005. PMID: 16081545 Free PMC article. Clinical Trial.
The likelihood of a positive ELISPOT (p = 0.0005) and a tuberculin skin test (p = 0.01) increased significantly with rising contact scores. ...Foreign-born, bacille Calmette-Guerin-vaccinated persons were significantly more likely to have a positive tuberculi …
The likelihood of a positive ELISPOT (p = 0.0005) and a tuberculin skin test (p = 0.01) increased significantly with rising co …
Use of T cell-based diagnosis of tuberculosis infection to optimize interpretation of tuberculin skin testing for child tuberculosis contacts.
Bakir M, Dosanjh DP, Deeks JJ, Soysal A, Millington KA, Efe S, Aslan Y, Polat D, Kodalli N, Yagci A, Barlan I, Bahceciler N, Demiralp EE, Lalvani A. Bakir M, et al. Among authors: lalvani a. Clin Infect Dis. 2009 Feb 1;48(3):302-12. doi: 10.1086/595847. Clin Infect Dis. 2009. PMID: 19123864 Free PMC article.
METHODS: A total of 979 child tuberculosis contacts in Istanbul underwent the TST and enzyme-linked immunospot assay. Using enzyme-linked immunospot test results as a reference standard, we assessed the effect of age and bacille Calmette-Guerin (BCG) vaccination on …
METHODS: A total of 979 child tuberculosis contacts in Istanbul underwent the TST and enzyme-linked immunospot assay. Using enzyme-li …
Improved diagnostic evaluation of suspected tuberculosis.
Dosanjh DP, Hinks TS, Innes JA, Deeks JJ, Pasvol G, Hackforth S, Varia H, Millington KA, Gunatheesan R, Guyot-Revol V, Lalvani A. Dosanjh DP, et al. Among authors: lalvani a. Ann Intern Med. 2008 Mar 4;148(5):325-36. doi: 10.7326/0003-4819-148-5-200803040-00003. Ann Intern Med. 2008. PMID: 18316751 Free PMC article.
INTERVENTION: Tuberculin skin testing, the enzyme-linked immunospot assay (ELISpot) incorporating early secretory antigenic target-6 and culture filtrate protein-10 (standard ELISpot), and ELISpot incorporating a novel antigen, Rv3879c (ELISpot(PLUS)) were performed during …
INTERVENTION: Tuberculin skin testing, the enzyme-linked immunospot assay (ELISpot) incorporating early secretory antigenic target-6 and cul …
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