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Targeting innate immunity for neurodegenerative disorders of the central nervous system.
Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica ML, Takata K, Teeling J, Town T, Van Eldik LJ. Andreasson KI, et al. J Neurochem. 2016 Sep;138(5):653-93. doi: 10.1111/jnc.13667. J Neurochem. 2016. PMID: 27248001 Free PMC article. Review.
ApoE promotes the proteolytic degradation of Abeta.
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. Jiang Q, et al. Neuron. 2008 Jun 12;58(5):681-93. doi: 10.1016/j.neuron.2008.04.010. Neuron. 2008. PMID: 18549781 Free PMC article.
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