Lambert MH - Search Results

1

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor.

Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. Watkins RE, et al. Among authors: lambert mh. J Mol Biol. 2003 Aug 22;331(4):815-28. doi: 10.1016/s0022-2836(03)00795-2. J Mol Biol. 2003. PMID: 12909012

2

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin.

Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. Watkins RE, et al. Among authors: lambert mh. Biochemistry. 2003 Feb 18;42(6):1430-8. doi: 10.1021/bi0268753. Biochemistry. 2003. PMID: 12578355

3

D3R Grand Challenge 3: blind prediction of protein-ligand poses and affinity rankings.

Gaieb Z, Parks CD, Chiu M, Yang H, Shao C, Walters WP, Lambert MH, Nevins N, Bembenek SD, Ameriks MK, Mirzadegan T, Burley SK, Amaro RE, Gilson MK. Gaieb Z, et al. Among authors: lambert mh. J Comput Aided Mol Des. 2019 Jan;33(1):1-18. doi: 10.1007/s10822-018-0180-4. Epub 2019 Jan 10. J Comput Aided Mol Des. 2019. PMID: 30632055 Free PMC article.

4

CSAR 2014: A Benchmark Exercise Using Unpublished Data from Pharma.

Carlson HA, Smith RD, Damm-Ganamet KL, Stuckey JA, Ahmed A, Convery MA, Somers DO, Kranz M, Elkins PA, Cui G, Peishoff CE, Lambert MH, Dunbar JB Jr. Carlson HA, et al. Among authors: lambert mh. J Chem Inf Model. 2016 Jun 27;56(6):1063-77. doi: 10.1021/acs.jcim.5b00523. Epub 2016 May 17. J Chem Inf Model. 2016. PMID: 27149958 Free PMC article.

5

Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist.

Sime M, Allan AC, Chapman P, Fieldhouse C, Giblin GM, Healy MP, Lambert MH, Leesnitzer LM, Lewis A, Merrihew RV, Rutter RA, Sasse R, Shearer BG, Willson TM, Xu RX, Virley DJ. Sime M, et al. Among authors: lambert mh. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Bioorg Med Chem Lett. 2011. PMID: 21798739

6

Phenoxyacetic acids as PPARδ partial agonists: synthesis, optimization, and in vivo efficacy.

Evans KA, Shearer BG, Wisnoski DD, Shi D, Sparks SM, Sternbach DD, Winegar DA, Billin AN, Britt C, Way JM, Epperly AH, Leesnitzer LM, Merrihew RV, Xu RX, Lambert MH, Jin J. Evans KA, et al. Among authors: lambert mh. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2345-50. doi: 10.1016/j.bmcl.2011.02.077. Epub 2011 Mar 15. Bioorg Med Chem Lett. 2011. PMID: 21414782

7

Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.

Phelan CA, Gampe RT Jr, Lambert MH, Parks DJ, Montana V, Bynum J, Broderick TM, Hu X, Williams SP, Nolte RT, Lazar MA. Phelan CA, et al. Among authors: lambert mh. Nat Struct Mol Biol. 2010 Jul;17(7):808-14. doi: 10.1038/nsmb.1860. Epub 2010 Jun 27. Nat Struct Mol Biol. 2010. PMID: 20581824 Free PMC article.

8

Discovery of a novel class of PPARdelta partial agonists.

Shearer BG, Patel HS, Billin AN, Way JM, Winegar DA, Lambert MH, Xu RX, Leesnitzer LM, Merrihew RV, Huet S, Willson TM. Shearer BG, et al. Among authors: lambert mh. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5018-22. doi: 10.1016/j.bmcl.2008.08.011. Epub 2008 Aug 9. Bioorg Med Chem Lett. 2008. PMID: 18722772

9

PPAR modulators and PPAR pan agonists for metabolic diseases: the next generation of drugs targeting peroxisome proliferator-activated receptors?

Feldman PL, Lambert MH, Henke BR. Feldman PL, et al. Among authors: lambert mh. Curr Top Med Chem. 2008;8(9):728-49. doi: 10.2174/156802608784535084. Curr Top Med Chem. 2008. PMID: 18537685 Review.

10

Co-crystal structure guided array synthesis of PPARgamma inverse agonists.

Trump RP, Cobb JE, Shearer BG, Lambert MH, Nolte RT, Willson TM, Buckholz RG, Zhao SM, Leesnitzer LM, Iannone MA, Pearce KH, Billin AN, Hoekstra WJ. Trump RP, et al. Among authors: lambert mh. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3916-20. doi: 10.1016/j.bmcl.2007.04.111. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17533125

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