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Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde.
Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ. Lamensdorf I, et al. J Neurosci Res. 2000 May 15;60(4):552-8. doi: 10.1002/(SICI)1097-4547(20000515)60:4<552::AID-JNR14>3.0.CO;2-U. J Neurosci Res. 2000. PMID: 10797558
Using inhibitors of mitochondrial complexes I, II, III and IV we found that inhibition of complex I and III increased levels of DOPAL and DOPET. ...Because complex I dysfunction has been implicated in the pathogenesis of Parkinson's disease, the accumulation …
Using inhibitors of mitochondrial complexes I, II, III and IV we found that inhibition of complex I and III increased levels o …
Effect of glipizide on dopamine synthesis, release and metabolism in PC12 cells.
Lamensdorf I, He L, Nechushtan A, Harvey-White J, Eisenhofer G, Milan R, Rojas E, Kopin IJ. Lamensdorf I, et al. Eur J Pharmacol. 2000 Jan 28;388(2):147-54. doi: 10.1016/s0014-2999(99)00839-0. Eur J Pharmacol. 2000. PMID: 10666506
3,4-Dihydroxyphenylacetaldehyde potentiates the toxic effects of metabolic stress in PC12 cells.
Lamensdorf I, Eisenhofer G, Harvey-White J, Nechustan A, Kirk K, Kopin IJ. Lamensdorf I, et al. Brain Res. 2000 Jun 23;868(2):191-201. doi: 10.1016/s0006-8993(00)02309-x. Brain Res. 2000. PMID: 10854571
In a previous study, we found that rotenone, a complex I inhibitor, induced a rapid accumulation of DOPAL and DOPET in the medium of cultured PC12 cells. ...Since complex I dysfunction is reported to be involved in the pathogenesis of Parkinson's disease, DOPAL pote …
In a previous study, we found that rotenone, a complex I inhibitor, induced a rapid accumulation of DOPAL and DOPET in the medium of …
Acidic dopamine metabolites are actively extruded from PC12 cells by a novel sulfonylurea-sensitive transporter.
Lamensdorf I, Hrycyna C, He LP, Nechushtan A, Tjurmina O, Harvey-White J, Eisenhofer G, Rojas E, Kopin IJ. Lamensdorf I, et al. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jun;361(6):654-64. doi: 10.1007/s002100000246. Naunyn Schmiedebergs Arch Pharmacol. 2000. PMID: 10882041
Effect of low-dose treatment with selegiline on dopamine transporter (DAT) expression and amphetamine-induced dopamine release in vivo.
Lamensdorf I, Porat S, Simantov R, Finberg JP. Lamensdorf I, et al. Br J Pharmacol. 1999 Feb;126(4):997-1002. doi: 10.1038/sj.bjp.0702389. Br J Pharmacol. 1999. PMID: 10193780 Free PMC article.
Chronic treatment with low doses of the selective monoamine oxidase (MAO) type B inhibitors selegiline [(-)-deprenyl] and rasagiline, causes elevation in extracellular level of 3,4-dihydroxyphenylethylamine (dopamine) in the rat striatum in vivo (Lamensdorf et al., 1996). …
Chronic treatment with low doses of the selective monoamine oxidase (MAO) type B inhibitors selegiline [(-)-deprenyl] and rasagiline, causes …
Sources and physiological significance of plasma dopamine sulfate.
Goldstein DS, Swoboda KJ, Miles JM, Coppack SW, Aneman A, Holmes C, Lamensdorf I, Eisenhofer G. Goldstein DS, et al. J Clin Endocrinol Metab. 1999 Jul;84(7):2523-31. doi: 10.1210/jcem.84.7.5864. J Clin Endocrinol Metab. 1999. PMID: 10404831
In this study, plasma concentrations of dopamine sulfate were measured after a meal, after fasting for 4 days, and during i.v. ...
In this study, plasma concentrations of dopamine sulfate were measured after a meal, after fasting for 4 days, and during i.v. ...
Modification of dopamine release by selective inhibitors of MAO-B.
Finberg JP, Lamensdorf I, Armoni T. Finberg JP, et al. Neurobiology (Bp). 2000;8(2):137-42. Neurobiology (Bp). 2000. PMID: 11061211
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis.
Nechushtan A, Smith CL, Lamensdorf I, Yoon SH, Youle RJ. Nechushtan A, et al. Among authors: lamensdorf i. J Cell Biol. 2001 Jun 11;153(6):1265-76. doi: 10.1083/jcb.153.6.1265. J Cell Biol. 2001. PMID: 11402069 Free PMC article.
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