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Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections.
Li T, Xue W, Zhang S, Wang H, Lan M, Zhang L, Lin M, Zhou M, Ying D, Zeng Y, Cui L, Yin Y, Chen H, Ma J, Liu C, Chen J, Wang C, Yu Z, Chen Y, Wu Y, Liu H, Li H, Zhang Y, Li J, Lu Z, Chen Z, Zhang Y, Yuan L, Zhou L, Zheng Q, Yu H, Zhang J, Cheng T, Chen J, Chen Y, Guan Y, Zheng Z, Gu Y, Xia N, Li S. Li T, et al. Nat Biomed Eng. 2026 Jul;10(7):1373-1391. doi: 10.1038/s41551-025-01529-y. Epub 2025 Oct 24. Nat Biomed Eng. 2026. PMID: 41136606
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N. Sun H, et al. Protein Cell. 2024 Feb 1;15(2):121-134. doi: 10.1093/procel/pwad040. Protein Cell. 2024. PMID: 37470320 Free PMC article.
Broad neutralizing antibody response of a monomeric spike-based SARS-CoV-2 bivalent vaccine against diverse variants.
Wang S, Sun H, Wang Y, Wang Z, Yuan L, Guo H, Gao J, Lan M, Wu Y, Shang H, Chen X, Chen Z, Hu J, Tang Z, Wen G, Ying D, Liu C, Jiang Y, Su J, Lin M, Wu T, Li S, Zhang T, Zhang J, Guan Y, Xia N, Yuan Q, Zheng Q, Zhang Y, Zheng Z. Wang S, et al. Proc Natl Acad Sci U S A. 2025 Sep 2;122(35):e2503254122. doi: 10.1073/pnas.2503254122. Epub 2025 Aug 25. Proc Natl Acad Sci U S A. 2025. PMID: 40854137 Free PMC article.
Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine.
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N. Wu Y, et al. Cell Host Microbe. 2022 Dec 14;30(12):1732-1744.e7. doi: 10.1016/j.chom.2022.10.011. Epub 2022 Oct 18. Cell Host Microbe. 2022. PMID: 36323313 Free PMC article.
1,472 results