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Development and applications of CRISPR-Cas9 for genome engineering.
Hsu PD, Lander ES, Zhang F. Hsu PD, et al. Among authors: lander es. Cell. 2014 Jun 5;157(6):1262-1278. doi: 10.1016/j.cell.2014.05.010. Cell. 2014. PMID: 24906146 Free PMC article. Review.
Gene expression correlates of clinical prostate cancer behavior.
Singh D, Febbo PG, Ross K, Jackson DG, Manola J, Ladd C, Tamayo P, Renshaw AA, D'Amico AV, Richie JP, Lander ES, Loda M, Kantoff PW, Golub TR, Sellers WR. Singh D, et al. Among authors: lander es. Cancer Cell. 2002 Mar;1(2):203-9. doi: 10.1016/s1535-6108(02)00030-2. Cancer Cell. 2002. PMID: 12086878
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia.
Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT. Ferrando AA, et al. Among authors: lander es. Cancer Cell. 2002 Feb;1(1):75-87. doi: 10.1016/s1535-6108(02)00018-1. Cancer Cell. 2002. PMID: 12086890
Anteroposterior patterning in hemichordates and the origins of the chordate nervous system.
Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M. Lowe CJ, et al. Among authors: lander e. Cell. 2003 Jun 27;113(7):853-65. doi: 10.1016/s0092-8674(03)00469-0. Cell. 2003. PMID: 12837244
Genomic maps and comparative analysis of histone modifications in human and mouse.
Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, Huebert DJ, McMahon S, Karlsson EK, Kulbokas EJ 3rd, Gingeras TR, Schreiber SL, Lander ES. Bernstein BE, et al. Among authors: lander es. Cell. 2005 Jan 28;120(2):169-81. doi: 10.1016/j.cell.2005.01.001. Cell. 2005. PMID: 15680324
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. Bernstein BE, et al. Among authors: lander es. Cell. 2006 Apr 21;125(2):315-26. doi: 10.1016/j.cell.2006.02.041. Cell. 2006. PMID: 16630819
We explored this by examining histone methylation in mouse embryonic stem (ES) cells across 56 large HCNE-rich loci. We identified a specific modification pattern, termed "bivalent domains," consisting of large regions of H3 lysine 27 methylation harboring smaller regions …
We explored this by examining histone methylation in mouse embryonic stem (ES) cells across 56 large HCNE-rich loci. We identified a …
Positive natural selection in the human lineage.
Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen TS, Altshuler D, Lander ES. Sabeti PC, et al. Among authors: lander es. Science. 2006 Jun 16;312(5780):1614-20. doi: 10.1126/science.1124309. Science. 2006. PMID: 16778047 Review.
The mammalian epigenome.
Bernstein BE, Meissner A, Lander ES. Bernstein BE, et al. Among authors: lander es. Cell. 2007 Feb 23;128(4):669-81. doi: 10.1016/j.cell.2007.01.033. Cell. 2007. PMID: 17320505 Review.
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC. Boehm JS, et al. Among authors: lander es. Cell. 2007 Jun 15;129(6):1065-79. doi: 10.1016/j.cell.2007.03.052. Cell. 2007. PMID: 17574021
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. Vasudevan KM, et al. Among authors: lander es. Cancer Cell. 2009 Jul 7;16(1):21-32. doi: 10.1016/j.ccr.2009.04.012. Cancer Cell. 2009. PMID: 19573809 Free PMC article.
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