Landgraf KE - Search Results

1

Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.

Landgraf KE, Pilling C, Falke JJ. Landgraf KE, et al. Biochemistry. 2008 Nov 25;47(47):12260-9. doi: 10.1021/bi801683k. Biochemistry. 2008. PMID: 18954143 Free PMC article.

2

Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.

Corbin JA, Evans JH, Landgraf KE, Falke JJ. Corbin JA, et al. Among authors: landgraf ke. Biochemistry. 2007 Apr 10;46(14):4322-36. doi: 10.1021/bi062140c. Epub 2007 Mar 17. Biochemistry. 2007. PMID: 17367165 Free PMC article.

3

Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.

Landgraf KE, Malmberg NJ, Falke JJ. Landgraf KE, et al. Biochemistry. 2008 Aug 12;47(32):8301-16. doi: 10.1021/bi800711t. Epub 2008 Jul 9. Biochemistry. 2008. PMID: 18610985 Free PMC article.

4

The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).

Pilling C, Landgraf KE, Falke JJ. Pilling C, et al. Among authors: landgraf ke. Biochemistry. 2011 Nov 15;50(45):9845-56. doi: 10.1021/bi2011306. Epub 2011 Oct 19. Biochemistry. 2011. PMID: 21932773 Free PMC article.

5

Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study.

Chen HC, Ziemba BP, Landgraf KE, Corbin JA, Falke JJ. Chen HC, et al. Among authors: landgraf ke. PLoS One. 2012;7(3):e33640. doi: 10.1371/journal.pone.0033640. Epub 2012 Mar 30. PLoS One. 2012. PMID: 22479423 Free PMC article.

6

Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α.

Ziemba BP, Li J, Landgraf KE, Knight JD, Voth GA, Falke JJ. Ziemba BP, et al. Among authors: landgraf ke. Biochemistry. 2014 Mar 18;53(10):1697-713. doi: 10.1021/bi4016082. Epub 2014 Mar 7. Biochemistry. 2014. PMID: 24559055 Free PMC article.

7

Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.

Lai CL, Landgraf KE, Voth GA, Falke JJ. Lai CL, et al. Among authors: landgraf ke. J Mol Biol. 2010 Sep 17;402(2):301-10. doi: 10.1016/j.jmb.2010.07.037. Epub 2010 Jul 24. J Mol Biol. 2010. PMID: 20659476 Free PMC article.

8

Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.

Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Hutchinson MR, et al. Neuroscience. 2010 Jun 30;168(2):551-63. doi: 10.1016/j.neuroscience.2010.03.067. Epub 2010 Apr 8. Neuroscience. 2010. PMID: 20381591 Free PMC article.

9

Evidence that opioids may have toll-like receptor 4 and MD-2 effects.

Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, Falke JJ, Leinwand LA, Maier SF, Yin H, Rice KC, Watkins LR. Hutchinson MR, et al. Among authors: landgraf ke. Brain Behav Immun. 2010 Jan;24(1):83-95. doi: 10.1016/j.bbi.2009.08.004. Epub 2009 Aug 11. Brain Behav Immun. 2010. PMID: 19679181 Free PMC article.

10

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.

Landgraf KE, Steffek M, Quan C, Tom J, Yu C, Santell L, Maun HR, Eigenbrot C, Lazarus RA. Landgraf KE, et al. Nat Chem Biol. 2014 Jul;10(7):567-73. doi: 10.1038/nchembio.1533. Epub 2014 May 25. Nat Chem Biol. 2014. PMID: 24859116

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