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p70s6k function is essential for G1 progression.
Lane HA, Fernandez A, Lamb NJ, Thomas G. Lane HA, et al. Nature. 1993 May 13;363(6425):170-2. doi: 10.1038/363170a0. Nature. 1993. PMID: 8483501
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR. Majumder PK, et al. Nat Med. 2004 Jun;10(6):594-601. doi: 10.1038/nm1052. Epub 2004 May 23. Nat Med. 2004. PMID: 15156201
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G. Beuvink I, et al. Cell. 2005 Mar 25;120(6):747-59. doi: 10.1016/j.cell.2004.12.040. Cell. 2005. PMID: 15797377
Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.
Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA. Breuleux M, et al. Mol Cancer Ther. 2009 Apr;8(4):742-53. doi: 10.1158/1535-7163.MCT-08-0668. Mol Cancer Ther. 2009. PMID: 19372546 Free PMC article.
The mammalian target of rapamycin kinase and tumor growth inhibition.
Boulay A, Lane HA. Boulay A, et al. Recent Results Cancer Res. 2007;172:99-124. doi: 10.1007/978-3-540-31209-3_7. Recent Results Cancer Res. 2007. PMID: 17607938 Review. No abstract available.
ERBB receptors and cancer: the complexity of targeted inhibitors.
Hynes NE, Lane HA. Hynes NE, et al. Nat Rev Cancer. 2005 May;5(5):341-54. doi: 10.1038/nrc1609. Nat Rev Cancer. 2005. PMID: 15864276 Review.
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.
Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, Tobler S, Heusser C, O'Reilly T, Stolz B, Marti A, Thomas G, Lane HA. Boulay A, et al. Cancer Res. 2004 Jan 1;64(1):252-61. doi: 10.1158/0008-5472.can-3554-2. Cancer Res. 2004. PMID: 14729632
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