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Management of Parkinson's disease a review of current and new therapies.
Mendis T, Suchowersky O, Lang A, Gauthier S. Mendis T, et al. Among authors: lang a. Can J Neurol Sci. 1999 May;26(2):89-103. Can J Neurol Sci. 1999. PMID: 10352867 Review.
New dopamine agonists which may have a levodopa "sparing effect;" it has been suggested that some of the drugs should be considered as first line treatments for newly diagnosed Parkinson's disease patients. ...A great deal more work needs to be done before a
New dopamine agonists which may have a levodopa "sparing effect;" it has been suggested that some of the drugs should be considered a …
A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa.
Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE. Rascol O, et al. Among authors: lang ae. N Engl J Med. 2000 May 18;342(20):1484-91. doi: 10.1056/NEJM200005183422004. N Engl J Med. 2000. PMID: 10816186 Clinical Trial.
BACKGROUND: There is debate about whether the initial treatment for patients with Parkinson's disease should be levodopa or a dopamine agonist. ...The analysis of the time to dyskinesia showed a significant difference in favor of ropinirole (hazard ratio for remaini …
BACKGROUND: There is debate about whether the initial treatment for patients with Parkinson's disease should be levodopa or a dopamin …
Parkinson's disease in 1984: an update.
Lang AE, Blair RD. Lang AE, et al. Can Med Assoc J. 1984 Nov 1;131(9):1031-7. Can Med Assoc J. 1984. PMID: 6388779 Free PMC article. Review.
The recent discovery of a highly selective neurotoxin (MPTP) that causes parkinsonism in humans and other primates and the use of positron emission tomography in living patients should improve our understanding of the cause of cell death in Parkinson's disease and assist i …
The recent discovery of a highly selective neurotoxin (MPTP) that causes parkinsonism in humans and other primates and the use of pos …
Treatment of Parkinson's disease with agents other than levodopa and dopamine agonists: controversies and new approaches.
Lang AE. Lang AE. Can J Neurol Sci. 1984 Feb;11(1 Suppl):210-20. doi: 10.1017/s0317167100046436. Can J Neurol Sci. 1984. PMID: 6143611
Parkinson's disease is associated with a variety of neurotransmitter disturbances which may be further altered by its treatment with dopamine agonists. Based on this information a wide range of pharmacological approaches have been used in search of newer treatment a …
Parkinson's disease is associated with a variety of neurotransmitter disturbances which may be further altered by its treatment with …
Painful Parkinson's disease.
Quinn NP, Koller WC, Lang AE, Marsden CD. Quinn NP, et al. Among authors: lang ae. Lancet. 1986 Jun 14;1(8494):1366-9. doi: 10.1016/s0140-6736(86)91674-0. Lancet. 1986. PMID: 2872480
A number of patients with Parkinson's disease complain of severe and distressing pain. Many of them are referred for psychiatric or other inappropriate treatment. ...
A number of patients with Parkinson's disease complain of severe and distressing pain. Many of them are referred for psychiatric or o
Levodopa in the treatment of Parkinson's disease: a consensus meeting.
Agid Y, Ahlskog E, Albanese A, Calne D, Chase T, De Yebenes J, Factor S, Fahn S, Gershanik O, Goetz C, Koller W, Kurth M, Lang A, Lees A, Lewitt P, Marsden D, Melamed E, Michel PP, Mizuno Y, Obeso J, Oertel W, Olanow W, Poewe W, Pollak P, Tolosa E, et al. Agid Y, et al. Among authors: lang a. Mov Disord. 1999 Nov;14(6):911-3. doi: 10.1002/1531-8257(199911)14:6<911::aid-mds1001>3.0.co;2-h. Mov Disord. 1999. PMID: 10584663 Review. No abstract available.
Manipulating the dopaminergic system in Parkinson's disease.
Lang AE. Lang AE. Pharmacol Ther. 1987;32(1):51-76. doi: 10.1016/0163-7258(87)90063-5. Pharmacol Ther. 1987. PMID: 3035589 Review. No abstract available.
Effect of GPi pallidotomy on motor function in Parkinson's disease.
Lozano AM, Lang AE, Galvez-Jimenez N, Miyasaki J, Duff J, Hutchinson WD, Dostrovsky JO. Lozano AM, et al. Among authors: lang ae. Lancet. 1995 Nov 25;346(8987):1383-7. doi: 10.1016/s0140-6736(95)92404-3. Lancet. 1995. PMID: 7475819 Clinical Trial.
Standardised videotape recordings before and after operation were randomised and scored by a "blinded' evaluator. 6 months after surgery, total motor score in the "off" state had improved by 30% and the total akinesia score by 33%. The gait score in the "off" state improve …
Standardised videotape recordings before and after operation were randomised and scored by a "blinded' evaluator. 6 months after surg …
Long-term follow-up of unilateral pallidotomy in advanced Parkinson's disease.
Fine J, Duff J, Chen R, Chir B, Hutchison W, Lozano AM, Lang AE. Fine J, et al. Among authors: lang ae. N Engl J Med. 2000 Jun 8;342(23):1708-14. doi: 10.1056/NEJM200006083422304. N Engl J Med. 2000. PMID: 10841873
METHODS: We conducted a long-term follow-up study of a cohort of 40 patients who had undergone unilateral posteroventral medial pallidotomy between 1993 and 1996. ...There was a sustained significant improvement in on-period contralateral dyskinesia but not i …
METHODS: We conducted a long-term follow-up study of a cohort of 40 patients who had undergone unilateral posteroventral media …
Dementia prevalence in Parkinson's disease.
Taylor A, Saint-Cyr JA, Lang AE. Taylor A, et al. Among authors: lang ae. Lancet. 1985 May 4;1(8436):1037. doi: 10.1016/s0140-6736(85)91631-9. Lancet. 1985. PMID: 2859479 No abstract available.
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