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Sec61 complexes form ubiquitous ER Ca2+ leak channels.
Lang S, Erdmann F, Jung M, Wagner R, Cavalie A, Zimmermann R. Lang S, et al. Channels (Austin). 2011 May-Jun;5(3):228-35. doi: 10.4161/chan.5.3.15314. Epub 2011 May 1. Channels (Austin). 2011. PMID: 21406962
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Hassdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J. Lang S, et al. J Cell Sci. 2012 Apr 15;125(Pt 8):1958-69. doi: 10.1242/jcs.096727. Epub 2012 Feb 28. J Cell Sci. 2012. PMID: 22375059 Free PMC article.
TRC40 can deliver short secretory proteins to the Sec61 translocon.
Johnson N, Vilardi F, Lang S, Leznicki P, Zimmermann R, High S. Johnson N, et al. Among authors: lang s. J Cell Sci. 2012 Aug 1;125(Pt 15):3612-20. doi: 10.1242/jcs.102608. Epub 2012 Apr 14. J Cell Sci. 2012. PMID: 22505607 Free PMC article.
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.
Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan Ö, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalié A, Zimmermann R. Schäuble N, et al. Among authors: lang s. EMBO J. 2012 Aug 1;31(15):3282-96. doi: 10.1038/emboj.2012.189. Epub 2012 Jul 13. EMBO J. 2012. PMID: 22796945 Free PMC article.
3,075 results