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Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor.
Oksvold MP, Thien CB, Widerberg J, Chantry A, Huitfeldt HS, Langdon WY. Oksvold MP, et al. Oncogene. 2003 Nov 20;22(52):8509-18. doi: 10.1038/sj.onc.1207117. Oncogene. 2003. PMID: 14627991
Regulation of the association of p120cbl with Grb2 in Jurkat T cells.
Donovan JA, Ota Y, Langdon WY, Samelson LE. Donovan JA, et al. J Biol Chem. 1996 Oct 18;271(42):26369-74. doi: 10.1074/jbc.271.42.26369. J Biol Chem. 1996. PMID: 8824292
The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.
Kirsch KH, Georgescu MM, Shishido T, Langdon WY, Birge RB, Hanafusa H. Kirsch KH, et al. J Biol Chem. 2001 Feb 16;276(7):4957-63. doi: 10.1074/jbc.M005784200. Epub 2000 Nov 6. J Biol Chem. 2001. PMID: 11067845
The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation.
Andoniou CE, Lill NL, Thien CB, Lupher ML Jr, Ota S, Bowtell DD, Scaife RM, Langdon WY, Band H. Andoniou CE, et al. Mol Cell Biol. 2000 Feb;20(3):851-67. doi: 10.1128/mcb.20.3.851-867.2000. Mol Cell Biol. 2000. PMID: 10629042 Free PMC article.
Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.
Bonita DP, Miyake S, Lupher ML Jr, Langdon WY, Band H. Bonita DP, et al. Mol Cell Biol. 1997 Aug;17(8):4597-610. doi: 10.1128/mcb.17.8.4597. Mol Cell Biol. 1997. PMID: 9234717 Free PMC article.
A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells.
Lupher ML Jr, Reedquist KA, Miyake S, Langdon WY, Band H. Lupher ML Jr, et al. J Biol Chem. 1996 Sep 27;271(39):24063-8. doi: 10.1074/jbc.271.39.24063. J Biol Chem. 1996. PMID: 8798643
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G.
Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H. Reedquist KA, et al. J Biol Chem. 1996 Apr 5;271(14):8435-42. doi: 10.1074/jbc.271.14.8435. J Biol Chem. 1996. PMID: 8626543
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