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Cystic fibrosis Delta F508 heterozygotes, smoking, and reproduction: studies of 9141 individuals from a general population sample.
Dahl M, Tybjaerg-Hansen A, Wittrup HH, Lange P, Nordestgaard BG. Dahl M, et al. Genomics. 1998 May 15;50(1):89-96. doi: 10.1006/geno.1998.5272. Genomics. 1998. PMID: 9628826
Among nonsmokers, heterozygotes had more children than noncarriers (Wilcoxon: P = 0.03). Among smokers, the opposite was found: heterozygotes had fewer children than noncarriers (Wilcoxon: P = 0. 001). ...Finally, after allowing for these covariates, number of child …
Among nonsmokers, heterozygotes had more children than noncarriers (Wilcoxon: P = 0.03). Among smokers, the opposite was found: heter …
Has risk associated with smoking increased? Results from the Copenhagen Center for Prospective Population Studies.
Prescott E, Osler M, Andersen PK, Bjerg A, Hein HO, Borch-Johnsen K, Lange P, Schnohr P, Vestbo J. Prescott E, et al. Int J Epidemiol. 1997 Dec;26(6):1214-8. doi: 10.1093/ije/26.6.1214. Int J Epidemiol. 1997. PMID: 9447400
Mortality in women and men in relation to smoking.
Prescott E, Osler M, Andersen PK, Hein HO, Borch-Johnsen K, Lange P, Schnohr P, Vestbo J. Prescott E, et al. Int J Epidemiol. 1998 Feb;27(1):27-32. doi: 10.1093/ije/27.1.27. Int J Epidemiol. 1998. PMID: 9563690
DeltaF508 heterozygosity in cystic fibrosis and susceptibility to asthma.
Dahl M, Tybjaerg-Hansen A, Lange P, Nordestgaard BG. Dahl M, et al. Lancet. 1998 Jun 27;351(9120):1911-3. doi: 10.1016/s0140-6736(97)11419-2. Lancet. 1998. PMID: 9654257
FINDINGS: We identified 250 carriers of the deltaF508 mutation (2.7% [95% CI 2.5-3.1]). 9% of carriers reported having asthma compared with 6% of non-carriers (p=0.04). The odds ratio for asthma in participants heterozygous for deltaF508 mutation was 2.0 (1.2-3.5, p
FINDINGS: We identified 250 carriers of the deltaF508 mutation (2.7% [95% CI 2.5-3.1]). 9% of carriers reported having asthma compared with …
Molecular diagnosis of intermediate and severe alpha(1)-antitrypsin deficiency: MZ individuals with chronic obstructive pulmonary disease may have lower lung function than MM individuals.
Dahl M, Nordestgaard BG, Lange P, Vestbo J, Tybjaerg-Hansen A. Dahl M, et al. Clin Chem. 2001 Jan;47(1):56-62. Clin Chem. 2001. PMID: 11148177
Genotype interacted with clinically established chronic obstructive pulmonary disease (COPD) on the percentage of the predicted FEV(1) (P = 0. 004): the percentage of the predicted FEV(1) was reduced in MZ compared with MM individuals among those with clinically establishe …
Genotype interacted with clinically established chronic obstructive pulmonary disease (COPD) on the percentage of the predicted FEV(1) (P
Lung function and risk of fatal and non-fatal stroke. The Copenhagen City Heart Study.
Truelsen T, Prescott E, Lange P, Schnohr P, Boysen G. Truelsen T, et al. Int J Epidemiol. 2001 Feb;30(1):145-51. doi: 10.1093/ije/30.1.145. Int J Epidemiol. 2001. PMID: 11171876
For each 10% decrease in FEV1 in percentage of expected, the relative risk (RR) increased 1.05 (95% CI : 1.00-1.09, P = 0.03). ...
For each 10% decrease in FEV1 in percentage of expected, the relative risk (RR) increased 1.05 (95% CI : 1.00-1.09, P = 0.03). ...
Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion.
Dahl M, Nordestgaard BG, Lange P, Tybjaerg-Hansen A. Dahl M, et al. J Allergy Clin Immunol. 2001 May;107(5):818-23. doi: 10.1067/mai.2001.114117. J Allergy Clin Immunol. 2001. PMID: 11344348
Cross-sectionally based on triple measurements, FEV(1) and FVC in individuals aged 20 to 70 years were lower in heterozygous participants versus noncarriers (P =.02 and P =.004, respectively). The average reduction of FEV(1) and FVC in DeltaF508 heterozygotes versus …
Cross-sectionally based on triple measurements, FEV(1) and FVC in individuals aged 20 to 70 years were lower in heterozygous participants ve …
Elevated plasma fibrinogen associated with reduced pulmonary function and increased risk of chronic obstructive pulmonary disease.
Dahl M, Tybjaerg-Hansen A, Vestbo J, Lange P, Nordestgaard BG. Dahl M, et al. Am J Respir Crit Care Med. 2001 Sep 15;164(6):1008-11. doi: 10.1164/ajrccm.164.6.2010067. Am J Respir Crit Care Med. 2001. PMID: 11587987
Individuals with plasma fibrinogen in the upper and middle tertile had COPD hospitalization rates of 93 and 60 compared with 52 per 10,000 person-years in individuals with fibrinogen in the lower tertile (log-rank: p < 0.001 and p = 0.31). ...
Individuals with plasma fibrinogen in the upper and middle tertile had COPD hospitalization rates of 93 and 60 compared with 52 per 10,000 p …
Cigarette smoking and asthma.
Ulrik CS, Lange P. Ulrik CS, et al. Monaldi Arch Chest Dis. 2001 Aug;56(4):349-53. Monaldi Arch Chest Dis. 2001. PMID: 11770219 Review.
Factor V leiden homozygosity, dyspnea, and reduced pulmonary function.
Juul K, Tybjaerg-Hansen A, Mortensen J, Lange P, Vestbo J, Nordestgaard BG. Juul K, et al. Arch Intern Med. 2005 Sep 26;165(17):2032-6. doi: 10.1001/archinte.165.17.2032. Arch Intern Med. 2005. PMID: 16186475
During follow-up, forced expiratory volume in 1 second and forced vital capacity were 5% to 10% lower in homozygotes vs noncarriers (analysis of variance; P = .003 and P = .03). The annual mean +/- SD loss of forced expiratory volume in 1 second and forced vital cap …
During follow-up, forced expiratory volume in 1 second and forced vital capacity were 5% to 10% lower in homozygotes vs noncarriers (analysi …
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