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Lanosterol reverses protein aggregation in cataracts.
Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Jefferson J, Perry P, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K. Zhao L, et al. Nature. 2015 Jul 30;523(7562):607-11. doi: 10.1038/nature14650. Epub 2015 Jul 22. Nature. 2015. PMID: 26200341
Any disruption of intra- or inter-protein interactions will alter this delicate structure, exposing hydrophobic surfaces, with consequent protein aggregation and cataract formation. ...Our study identifies lanosterol as a key molecule in the pre …
Any disruption of intra- or inter-protein interactions will alter this delicate structure, exposing hydrophobic surfaces, with conseq …
Corrigendum: Lanosterol reverses protein aggregation in cataracts.
Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, Lin Y, Chen D, Wen C, Chung C, Wang Y, Qiu A, Yeh E, Wang W, Hu X, Grob S, Abagyan R, Su Z, Tjondro HC, Zhao XJ, Luo H, Hou R, Perry JJ, Gao W, Kozak I, Granet D, Li Y, Sun X, Wang J, Zhang L, Liu Y, Yan YB, Zhang K. Zhao L, et al. Nature. 2015 Oct 22;526(7574):595. doi: 10.1038/nature15253. Epub 2015 Aug 26. Nature. 2015. PMID: 26308894 No abstract available.
Advances in pharmacotherapy of cataracts.
Xu J, Fu Q, Chen X, Yao K. Xu J, et al. Ann Transl Med. 2020 Nov;8(22):1552. doi: 10.21037/atm-20-1960. Ann Transl Med. 2020. PMID: 33313297 Free PMC article. Review.
Cataracts, the leading cause of vision impairment worldwide, arise from abnormal aggregation of lens proteins. ...Makley and Zhao recently identified two kinds of novel pharmacological substances (25-hydroxycholesterol, lanosterol) that can reverse
Cataracts, the leading cause of vision impairment worldwide, arise from abnormal aggregation of lens proteins. ...Makle
Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.
Yang X, Chen XJ, Yang Z, Xi YB, Wang L, Wu Y, Yan YB, Rao Y. Yang X, et al. J Med Chem. 2018 Oct 11;61(19):8693-8706. doi: 10.1021/acs.jmedchem.8b00705. Epub 2018 Sep 24. J Med Chem. 2018. PMID: 30153006
We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and gener …
We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse
The quest for homeopathic and nonsurgical cataract treatment.
Lian RR, Afshari NA. Lian RR, et al. Curr Opin Ophthalmol. 2020 Jan;31(1):61-66. doi: 10.1097/ICU.0000000000000631. Curr Opin Ophthalmol. 2020. PMID: 31770163 Review.
PURPOSE OF REVIEW: Age-related cataract occurs when crystallin proteins in the lens partially unfold and subsequently aggregate. ...However, in recent years, scientists have begun to investigate substances that address cataract by reversing lens …
PURPOSE OF REVIEW: Age-related cataract occurs when crystallin proteins in the lens partially unfold and subsequently aggre
Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts.
Daszynski DM, Santhoshkumar P, Phadte AS, Sharma KK, Zhong HA, Lou MF, Kador PF. Daszynski DM, et al. Sci Rep. 2019 Jun 11;9(1):8459. doi: 10.1038/s41598-019-44676-4. Sci Rep. 2019. PMID: 31186457 Free PMC article.
Subsequent 48-hour incubation with 15 mM of lanosterol liposomes failed to either reverse these lens opacities or prevent the further progression of cataracts to the nuclear stage. ...In summary, all three studies failed to provide evidence that lanosterol
Subsequent 48-hour incubation with 15 mM of lanosterol liposomes failed to either reverse these lens opacities or prevent the …
Pathogenic mechanism of congenital cataract caused by the CRYBA1/A3-G91del variant and related intervention strategies.
Xu J, Wang H, Wu C, Wang A, Wu W, Xu J, Luo C, Ni S, Yao K, Chen X. Xu J, et al. Int J Biol Macromol. 2021 Oct 31;189:44-52. doi: 10.1016/j.ijbiomac.2021.08.111. Epub 2021 Aug 19. Int J Biol Macromol. 2021. PMID: 34419537
Next, we constructed a CRYBA1/BA3 mutant cell model and observed that G91del mutant proteins were more sensitive to environmental stress and prone to form aggregates. ...Finally, we investigated intervention strategies for congenital cataract caused by the CR …
Next, we constructed a CRYBA1/BA3 mutant cell model and observed that G91del mutant proteins were more sensitive to environmental str …
Effect of lanosterol on human cataract nucleus.
Shanmugam PM, Barigali A, Kadaskar J, Borgohain S, Mishra DK, Ramanjulu R, Minija CK. Shanmugam PM, et al. Indian J Ophthalmol. 2015 Dec;63(12):888-90. doi: 10.4103/0301-4738.176040. Indian J Ophthalmol. 2015. PMID: 26862091 Free PMC article.
AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanos
AIM: To study the effect of lanosterol on age-related cataractous human lens nuclei. MATERIALS AND METHODS: Forty age-related …
Cataract-causing mutations S78F and S78P of gammaD-crystallin decrease protein conformational stability and drive aggregation.
Lin N, Zhang Y, Song X, Xu J, Luo C, Tian Q, Yao K, Wu W, Chen X, Hu L. Lin N, et al. Int J Biol Macromol. 2023 Dec 31;253(Pt 4):126910. doi: 10.1016/j.ijbiomac.2023.126910. Epub 2023 Sep 21. Int J Biol Macromol. 2023. PMID: 37739288
The environmental stresses (including heat, ultraviolet irradiation and oxidative stress) promoted the formation of aggregates. Moreover, the intracellular S78F and S78P aggregates could be reversed by lanosterol. ...Hence, our results reveal the vital …
The environmental stresses (including heat, ultraviolet irradiation and oxidative stress) promoted the formation of aggregates. Moreo …
betaB2 W151R mutant is prone to degradation, aggregation and exposes the hydrophobic side chains in the fourth Greek Key motif.
Xu J, Wang H, Wang A, Xu J, Fu C, Jia Z, Yao K, Chen X. Xu J, et al. Biochim Biophys Acta Mol Basis Dis. 2021 Feb 1;1867(2):166018. doi: 10.1016/j.bbadis.2020.166018. Epub 2020 Nov 25. Biochim Biophys Acta Mol Basis Dis. 2021. PMID: 33246011 Free article.
However, upon the administration of lanosterol, the negative effect of the W151R mutation was reversed. Therefore, lanosterol is a potential therapeutic option for cataracts....
However, upon the administration of lanosterol, the negative effect of the W151R mutation was reversed. Therefore, lanoster
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