Lansbury PT Jr - Search Results

1

Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice.

Cuddy LK, Alia AO, Salvo MA, Chandra S, Grammatopoulos TN, Justman CJ, Lansbury PT Jr, Mazzulli JR, Vassar R. Cuddy LK, et al. Among authors: lansbury pt jr. Mol Neurodegener. 2022 Aug 20;17(1):54. doi: 10.1186/s13024-022-00561-9. Mol Neurodegener. 2022. PMID: 35987691 Free PMC article.

2

Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.

Cuddy LK, Wani WY, Morella ML, Pitcairn C, Tsutsumi K, Fredriksen K, Justman CJ, Grammatopoulos TN, Belur NR, Zunke F, Subramanian A, Affaneh A, Lansbury PT Jr, Mazzulli JR. Cuddy LK, et al. Among authors: lansbury pt jr. Neuron. 2019 Dec 4;104(5):869-884.e11. doi: 10.1016/j.neuron.2019.09.001. Epub 2019 Oct 21. Neuron. 2019. PMID: 31648898 Free PMC article.

3

N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast.

Vamvaca K, Lansbury PT Jr, Stefanis L. Vamvaca K, et al. Among authors: lansbury pt jr. J Neurochem. 2011 Oct;119(2):389-97. doi: 10.1111/j.1471-4159.2011.07431.x. Epub 2011 Sep 20. J Neurochem. 2011. PMID: 21848810 Free PMC article.

4

The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast.

Vamvaca K, Volles MJ, Lansbury PT Jr. Vamvaca K, et al. Among authors: lansbury pt jr. J Mol Biol. 2009 Jun 5;389(2):413-24. doi: 10.1016/j.jmb.2009.03.021. Epub 2009 Mar 13. J Mol Biol. 2009. PMID: 19285989 Free PMC article.

5

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.

Liu Z, Meray RK, Grammatopoulos TN, Fredenburg RA, Cookson MR, Liu Y, Logan T, Lansbury PT Jr. Liu Z, et al. Among authors: lansbury pt jr. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4635-40. doi: 10.1073/pnas.0806474106. Epub 2009 Mar 4. Proc Natl Acad Sci U S A. 2009. PMID: 19261853 Free PMC article.

6

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA. Paleologou KE, et al. Among authors: lansbury pt jr. J Biol Chem. 2008 Jun 13;283(24):16895-905. doi: 10.1074/jbc.M800747200. Epub 2008 Mar 14. J Biol Chem. 2008. PMID: 18343814 Free PMC article.

7

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.

Fredenburg RA, Rospigliosi C, Meray RK, Kessler JC, Lashuel HA, Eliezer D, Lansbury PT Jr. Fredenburg RA, et al. Among authors: lansbury pt jr. Biochemistry. 2007 Jun 19;46(24):7107-18. doi: 10.1021/bi7000246. Epub 2007 May 26. Biochemistry. 2007. PMID: 17530780

8

Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1.

Meray RK, Lansbury PT Jr. Meray RK, et al. Among authors: lansbury pt jr. J Biol Chem. 2007 Apr 6;282(14):10567-75. doi: 10.1074/jbc.M611153200. Epub 2007 Jan 26. J Biol Chem. 2007. PMID: 17259170 Free article.

9

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity.

Volles MJ, Lansbury PT Jr. Volles MJ, et al. Among authors: lansbury pt jr. J Mol Biol. 2007 Mar 9;366(5):1510-22. doi: 10.1016/j.jmb.2006.12.044. Epub 2006 Dec 21. J Mol Biol. 2007. PMID: 17222866 Free PMC article.

10

Substrate recognition and catalysis by UCH-L1.

Luchansky SJ, Lansbury PT Jr, Stein RL. Luchansky SJ, et al. Among authors: lansbury pt jr. Biochemistry. 2006 Dec 12;45(49):14717-25. doi: 10.1021/bi061406c. Biochemistry. 2006. PMID: 17144664

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