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Sequence requirements for cytochrome P-450IIB1 catalytic activity. Alteration of the stereospecificity and regioselectivity of steroid hydroxylation by a simultaneous change of two hydrophobic amino acid residues to phenylalanine.
Aoyama T, Korzekwa K, Nagata K, Adesnik M, Reiss A, Lapenson DP, Gillette J, Gelboin HV, Waxman DJ, Gonzalez FJ. Aoyama T, et al. Among authors: lapenson dp. J Biol Chem. 1989 Dec 15;264(35):21327-33. J Biol Chem. 1989. PMID: 2574176 Free article.
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al. Aoyama T, et al. Among authors: lapenson dp. J Biol Chem. 1989 Jun 25;264(18):10388-95. J Biol Chem. 1989. PMID: 2732228
Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase.
Matsunaga T, Nagata K, Holsztynska EJ, Lapenson DP, Smith A, Kato R, Gelboin HV, Waxman DJ, Gonzalez FJ. Matsunaga T, et al. Among authors: lapenson dp. J Biol Chem. 1988 Dec 5;263(34):17995-8002. J Biol Chem. 1988. PMID: 3192524
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