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109 results
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Xpd/Ercc2 regulates CAK activity and mitotic progression.
Chen J, Larochelle S, Li X, Suter B. Chen J, et al. Among authors: larochelle s. Nature. 2003 Jul 10;424(6945):228-32. doi: 10.1038/nature01746. Nature. 2003. PMID: 12853965
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.
Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV. Burkard ME, et al. Among authors: larochelle s. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4383-8. doi: 10.1073/pnas.0701140104. Epub 2007 Mar 6. Proc Natl Acad Sci U S A. 2007. PMID: 17360533 Free PMC article.
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP. Larochelle S, et al. Mol Cell. 2007 Mar 23;25(6):839-50. doi: 10.1016/j.molcel.2007.02.003. Mol Cell. 2007. PMID: 17386261 Free PMC article.
Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.
Kalan S, Amat R, Schachter MM, Kwiatkowski N, Abraham BJ, Liang Y, Zhang T, Olson CM, Larochelle S, Young RA, Gray NS, Fisher RP. Kalan S, et al. Among authors: larochelle s. Cell Rep. 2017 Oct 10;21(2):467-481. doi: 10.1016/j.celrep.2017.09.056. Cell Rep. 2017. PMID: 29020632 Free PMC article.
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
Wohlbold L, Merrick KA, De S, Amat R, Kim JH, Larochelle S, Allen JJ, Zhang C, Shokat KM, Petrini JH, Fisher RP. Wohlbold L, et al. Among authors: larochelle s. PLoS Genet. 2012 Aug;8(8):e1002935. doi: 10.1371/journal.pgen.1002935. Epub 2012 Aug 23. PLoS Genet. 2012. PMID: 22927831 Free PMC article.
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. Larochelle S, et al. Nat Struct Mol Biol. 2012 Nov;19(11):1108-15. doi: 10.1038/nsmb.2399. Epub 2012 Oct 14. Nat Struct Mol Biol. 2012. PMID: 23064645 Free PMC article.
p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.
Ray A, James MK, Larochelle S, Fisher RP, Blain SW. Ray A, et al. Among authors: larochelle s. Mol Cell Biol. 2009 Feb;29(4):986-99. doi: 10.1128/MCB.00898-08. Epub 2008 Dec 15. Mol Cell Biol. 2009. PMID: 19075005 Free PMC article.
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.
Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP. Merrick KA, et al. Among authors: larochelle s. Mol Cell. 2008 Dec 5;32(5):662-72. doi: 10.1016/j.molcel.2008.10.022. Mol Cell. 2008. PMID: 19061641 Free PMC article.
Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y. Sordet O, et al. Among authors: larochelle s. J Mol Biol. 2008 Sep 5;381(3):540-9. doi: 10.1016/j.jmb.2008.06.028. Epub 2008 Jun 17. J Mol Biol. 2008. PMID: 18588899 Free PMC article.
The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity.
Wohlbold L, Larochelle S, Liao JC, Livshits G, Singer J, Shokat KM, Fisher RP. Wohlbold L, et al. Among authors: larochelle s. Cell Cycle. 2006 Mar;5(5):546-54. doi: 10.4161/cc.5.5.2541. Epub 2006 Mar 1. Cell Cycle. 2006. PMID: 16552187
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