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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. Liang J, et al. Among authors: Larrea M. Nat Cell Biol. 2007 Feb;9(2):218-24. doi: 10.1038/ncb1537. Epub 2007 Jan 21. Nat Cell Biol. 2007. PMID: 17237771
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation.
Hong F, Larrea MD, Doughty C, Kwiatkowski DJ, Squillace R, Slingerland JM. Hong F, et al. Among authors: Larrea MD. Mol Cell. 2008 Jun 20;30(6):701-11. doi: 10.1016/j.molcel.2008.04.027. Mol Cell. 2008. PMID: 18570873
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.
Larrea MD, Liang J, Da Silva T, Hong F, Shao SH, Han K, Dumont D, Slingerland JM. Larrea MD, et al. Mol Cell Biol. 2008 Oct;28(20):6462-72. doi: 10.1128/MCB.02300-07. Epub 2008 Aug 18. Mol Cell Biol. 2008. PMID: 18710949 Free PMC article.
Kidney and uro-trauma: WSES-AAST guidelines.
Coccolini F, Moore EE, Kluger Y, Biffl W, Leppaniemi A, Matsumura Y, Kim F, Peitzman AB, Fraga GP, Sartelli M, Ansaloni L, Augustin G, Kirkpatrick A, Abu-Zidan F, Wani I, Weber D, Pikoulis E, Larrea M, Arvieux C, Manchev V, Reva V, Coimbra R, Khokha V, Mefire AC, Ordonez C, Chiarugi M, Machado F, Sakakushev B, Matsumoto J, Maier R, di Carlo I, Catena F; WSES-AAST Expert Panel. Coccolini F, et al. Among authors: Larrea M. World J Emerg Surg. 2019 Dec 2;14:54. doi: 10.1186/s13017-019-0274-x. eCollection 2019. World J Emerg Surg. 2019. PMID: 31827593 Free PMC article. Review.
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