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Diets with high or low protein content and glycemic index for weight-loss maintenance.
Larsen TM, Dalskov SM, van Baak M, Jebb SA, Papadaki A, Pfeiffer AF, Martinez JA, Handjieva-Darlenska T, Kunešová M, Pihlsgård M, Stender S, Holst C, Saris WH, Astrup A; Diet, Obesity, and Genes (Diogenes) Project. Larsen TM, et al. N Engl J Med. 2010 Nov 25;363(22):2102-13. doi: 10.1056/NEJMoa1007137. N Engl J Med. 2010. PMID: 21105792 Free PMC article. Clinical Trial.
METHODS: We enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. Participants were randomly assigned, in a two-by-two factorial design, to one of five ad libi …
METHODS: We enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a 3.3 …
A carbohydrate-reduced high-protein diet improves HbA(1c) and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial.
Skytte MJ, Samkani A, Petersen AD, Thomsen MN, Astrup A, Chabanova E, Frystyk J, Holst JJ, Thomsen HS, Madsbad S, Larsen TM, Haugaard SB, Krarup T. Skytte MJ, et al. Among authors: larsen tm. Diabetologia. 2019 Nov;62(11):2066-2078. doi: 10.1007/s00125-019-4956-4. Epub 2019 Jul 23. Diabetologia. 2019. PMID: 31338545 Clinical Trial.
AIMS/HYPOTHESIS: Dietary recommendations for treating type 2 diabetes are unclear but a trend towards recommending a diet reduced in carbohydrate content is acknowledged. We compared a carbohydrate-reduced high-protein (CRHP) diet with an iso-en …
AIMS/HYPOTHESIS: Dietary recommendations for treating type 2 diabetes are unclear but a trend towards recommending a diet reduced in …
The PREVIEW intervention study: Results from a 3-year randomized 2 x 2 factorial multinational trial investigating the role of protein, glycaemic index and physical activity for prevention of type 2 diabetes.
Raben A, Vestentoft PS, Brand-Miller J, Jalo E, Drummen M, Simpson L, Martinez JA, Handjieva-Darlenska T, Stratton G, Huttunen-Lenz M, Lam T, Sundvall J, Muirhead R, Poppitt S, Ritz C, Pietiläinen KH, Westerterp-Plantenga M, Taylor MA, Navas-Carretero S, Handjiev S, McNarry MA, Hansen S, Råman L, Brodie S, Silvestre MP, Adam TC, Macdonald IA, San-Cristobal R, Boyadjieva N, Mackintosh KA, Schlicht W, Liu A, Larsen TM, Fogelholm M. Raben A, et al. Among authors: larsen tm. Diabetes Obes Metab. 2021 Feb;23(2):324-337. doi: 10.1111/dom.14219. Epub 2020 Nov 3. Diabetes Obes Metab. 2021. PMID: 33026154
AIM: To compare the impact of two long-term weight-maintenance diets, a high protein (HP) and low glycaemic index (GI) diet versus a moderate protein (MP) and moderate GI diet, combined with either hi
AIM: To compare the impact of two long-term weight-maintenance diets, a high protein (HP) and low
PREVIEW: Prevention of Diabetes through Lifestyle Intervention and Population Studies in Europe and around the World. Design, Methods, and Baseline Participant Description of an Adult Cohort Enrolled into a Three-Year Randomised Clinical Trial.
Fogelholm M, Larsen TM, Westerterp-Plantenga M, Macdonald I, Martinez JA, Boyadjieva N, Poppitt S, Schlicht W, Stratton G, Sundvall J, Lam T, Jalo E, Christensen P, Drummen M, Simpson E, Navas-Carretero S, Handjieva-Darlenska T, Muirhead R, Silvestre MP, Kahlert D, Pastor-Sanz L, Brand-Miller J, Raben A. Fogelholm M, et al. Among authors: larsen tm. Nutrients. 2017 Jun 20;9(6):632. doi: 10.3390/nu9060632. Nutrients. 2017. PMID: 28632180 Free PMC article.
The study is a three-year multi-centre, 2 2 factorial, randomised controlled trial. The impact of a high-protein, low-glycaemic index (GI) vs. moderate protein, moderate-GI diet in combination with moderate or high-intensity …
The study is a three-year multi-centre, 2 2 factorial, randomised controlled trial. The impact of a high-protein, low- …
Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention.
Hjorth MF, Roager HM, Larsen TM, Poulsen SK, Licht TR, Bahl MI, Zohar Y, Astrup A. Hjorth MF, et al. Among authors: larsen tm. Int J Obes (Lond). 2018 Mar;42(3):580-583. doi: 10.1038/ijo.2017.220. Epub 2017 Sep 8. Int J Obes (Lond). 2018. PMID: 28883543 Free PMC article. Clinical Trial.
Among individuals with high P/B the NND resulted in a 3.15 kg (95% confidence interval (CI): 1.55; 4.76, P<0.001) larger body fat loss compared with ADD, whereas no differences was observed among individuals with low P/B (0.88 kg (95% …
Among individuals with high P/B the NND resulted in a 3.15 kg (95% confidence interval (CI): 1.55; 4.76, P<0.001) la …
The Diet, Obesity and Genes (Diogenes) Dietary Study in eight European countries - a comprehensive design for long-term intervention.
Larsen TM, Dalskov S, van Baak M, Jebb S, Kafatos A, Pfeiffer A, Martinez JA, Handjieva-Darlenska T, Kunesová M, Holst C, Saris WH, Astrup A. Larsen TM, et al. Obes Rev. 2010 Jan;11(1):76-91. doi: 10.1111/j.1467-789X.2009.00603.x. Epub 2009 May 28. Obes Rev. 2010. PMID: 19470086 Free article. Clinical Trial.
A total of 891 families with at least one overweight/obese parent underwent screening. The parents started an initial 8-week low-calorie diet and families with minimum one parent attaining a weight loss of > or = 8%, were randomized to one of five e …
A total of 891 families with at least one overweight/obese parent underwent screening. The parents started an initial 8-week low-calo …
Weight loss at your fingertips: personalized nutrition with fasting glucose and insulin using a novel statistical approach.
Ritz C, Astrup A, Larsen TM, Hjorth MF. Ritz C, et al. Among authors: larsen tm. Eur J Clin Nutr. 2019 Nov;73(11):1529-1535. doi: 10.1038/s41430-019-0423-z. Epub 2019 Apr 9. Eur J Clin Nutr. 2019. PMID: 30967642 Clinical Trial.
RESULTS: Every mmol/L increase in baseline FPG predicted a between-diet difference of 3.00 (1.18;4.83, n = 181, P = 0.001) kg larger weight loss from choosing NND over ADD. ...Among individuals with FPG <5.6 mmol/L, each pmol/L lower baseline FI pre …
RESULTS: Every mmol/L increase in baseline FPG predicted a between-diet difference of 3.00 (1.18;4.83, n = 181, P = 0.001) kg …
Effects of carbohydrate restriction on postprandial glucose metabolism, β-cell function, gut hormone secretion, and satiety in patients with Type 2 diabetes.
Skytte MJ, Samkani A, Astrup A, Frystyk J, Rehfeld JF, Holst JJ, Madsbad S, Burling K, Fenger M, Thomsen MN, Larsen TM, Krarup T, Haugaard SB. Skytte MJ, et al. Among authors: larsen tm. Am J Physiol Endocrinol Metab. 2021 Jan 1;320(1):E7-E18. doi: 10.1152/ajpendo.00165.2020. Epub 2020 Oct 26. Am J Physiol Endocrinol Metab. 2021. PMID: 33103448
Methods In a crossover design, 28 T2D patients (mean HbA(1c): 60 mmol/mol) were randomized to 6 wk of carbohydrate-reduced high-protein (CRHP) diet and 6 wk of conventional diabetes (CD) diet (energy-percentage carbohydrate/protein/fat: 30/30/40 …
Methods In a crossover design, 28 T2D patients (mean HbA(1c): 60 mmol/mol) were randomized to 6 wk of carbohydrate-reduced high-pr
Pretreatment Prevotella-to-Bacteroides ratio and salivary amylase gene copy number as prognostic markers for dietary weight loss.
Hjorth MF, Christensen L, Larsen TM, Roager HM, Krych L, Kot W, Nielsen DS, Ritz C, Astrup A. Hjorth MF, et al. Among authors: larsen tm. Am J Clin Nutr. 2020 May 1;111(5):1079-1086. doi: 10.1093/ajcn/nqaa007. Am J Clin Nutr. 2020. PMID: 32034403 Clinical Trial.
No such differences in weight loss were found among subjects in both groups with high AMY1 CN [-0.17 kg/unit (95% CI: -1.01, 0.66; n = 24; P = 0.68)]. CONCLUSIONS: The combined use of low AMY1 CN and pretreatment P/B ratio for weight
No such differences in weight loss were found among subjects in both groups with high AMY1 CN [-0.17 kg/unit (95% CI: - …
Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results.
Aller EE, Larsen TM, Claus H, Lindroos AK, Kafatos A, Pfeiffer A, Martinez JA, Handjieva-Darlenska T, Kunesova M, Stender S, Saris WH, Astrup A, van Baak MA. Aller EE, et al. Among authors: larsen tm. Int J Obes (Lond). 2014 Dec;38(12):1511-7. doi: 10.1038/ijo.2014.52. Epub 2014 Mar 28. Int J Obes (Lond). 2014. PMID: 24675714 Clinical Trial.
BACKGROUND: A high dietary protein (P) content and low glycemic index (LGI) have been suggested to be beneficial for weight management, but long-term studies are scarce. ...CONCLUSION: A higher protein content
BACKGROUND: A high dietary protein (P) content and low glycemic index (LGI) have been sugge …
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