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DNA methylation alterations in response to prenatal exposure of maternal cigarette smoking: A persistent epigenetic impact on health from maternal lifestyle?
Nielsen CH, Larsen A, Nielsen AL. Nielsen CH, et al. Arch Toxicol. 2016 Feb;90(2):231-45. doi: 10.1007/s00204-014-1426-0. Epub 2014 Dec 6. Arch Toxicol. 2016. PMID: 25480659 Review.
Despite increased awareness, maternal cigarette smoking during pregnancy continues to be a common habit causing risk for numerous documented negative health consequences in the exposed children. ...Further, a number of specific genes exemplified by CYP1A1, AhRR, FOX …
Despite increased awareness, maternal cigarette smoking during pregnancy continues to be a common habit causing risk for numerous doc …
Gastrointestinal and systemic uptake of bismuth in mice after oral exposure.
Larsen A, Martiny N, Stoltenberg M, Danscher G, Rungby J. Larsen A, et al. Pharmacol Toxicol. 2003 Aug;93(2):82-90. Pharmacol Toxicol. 2003. PMID: 12899670
In recent years, bismuth has gained renewed interest as a remedy for eradication of gastrointestinal pathogens, especially Helicobacter pylori. In this study we describe the anatomical distribution of bismuth in the gastrointestinal tract and other organs after oral exposu …
In recent years, bismuth has gained renewed interest as a remedy for eradication of gastrointestinal pathogens, especially Helicobact …
Influence of bismuth on the number of neurons in cerebellum and hippocampus of normal and hypoxia-exposed mouse brain: a stereological study.
Larsen A, Stoltenberg M, West MJ, Danscher G. Larsen A, et al. J Appl Toxicol. 2005 Sep-Oct;25(5):383-92. doi: 10.1002/jat.1061. J Appl Toxicol. 2005. PMID: 16013041
Bismuth-induced encephalopathy is a known side-effect. One of the symptoms of bismuth encephalopathy is ataxia, suggesting possible cerebellar involvement. ...Surprisingly, intermittent hypoxia led to a statistically significant loss of Purkinje cells without affect …
Bismuth-induced encephalopathy is a known side-effect. One of the symptoms of bismuth encephalopathy is ataxia, suggesting possible c …
In vivo distribution of bismuth in the mouse brain: influence of long-term survival and intracranial placement on the uptake and transport of bismuth in neuronal tissue.
Larsen A, Stoltenberg M, Søndergaard C, Bruhn M, Danscher G. Larsen A, et al. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):188-96. doi: 10.1111/j.1742-7843.2005.pto_973132.x. Basic Clin Pharmacol Toxicol. 2005. PMID: 16128915
Bismuth is used for a multitude of industrial purposes and has partly replaced toxic heavy metals such as lead and mercury in e.g. lubricants and shotgun pellets. ...
Bismuth is used for a multitude of industrial purposes and has partly replaced toxic heavy metals such as lead and mercury in e.g. lu …
Kupffer cells are central in the removal of nanoparticles from the organism.
Sadauskas E, Wallin H, Stoltenberg M, Vogel U, Doering P, Larsen A, Danscher G. Sadauskas E, et al. Part Fibre Toxicol. 2007 Oct 19;4:10. doi: 10.1186/1743-8977-4-10. Part Fibre Toxicol. 2007. PMID: 17949501 Free PMC article.
IV injections resulted in a rapid accumulation/clustering of nanoparticles in these liver macrophages, while the uptake in spleen macrophages was moderate. IP injections were followed by a delayed uptake in the liver and included a moderate uptake in macropha …
IV injections resulted in a rapid accumulation/clustering of nanoparticles in these liver macrophages, while the uptake in spleen mac …
Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney.
Jakobsen SS, Danscher G, Stoltenberg M, Larsen A, Bruun JM, Mygind T, Kemp K, Soballe K. Jakobsen SS, et al. Basic Clin Pharmacol Toxicol. 2007 Dec;101(6):441-6. doi: 10.1111/j.1742-7843.2007.00137.x. Epub 2007 Oct 25. Basic Clin Pharmacol Toxicol. 2007. PMID: 17971067
Nine months after implanting small pieces of CoCrMo alloy intramuscularly and intraperitoneally in rats, we analysed the accumulation of metals with a multi-element analysis, and the levels of metallothionein I/II with real-time reverse transcriptase-polymerase chain react …
Nine months after implanting small pieces of CoCrMo alloy intramuscularly and intraperitoneally in rats, we analysed the accumulation of met …
Metallic silver fragments cause massive tissue loss in the mouse brain.
Locht LJ, Pedersen MØ, Markholt S, Bibby BM, Larsen A, Penkowa M, Stoltenberg M, Rungby J. Locht LJ, et al. Basic Clin Pharmacol Toxicol. 2011 Jul;109(1):1-10. doi: 10.1111/j.1742-7843.2010.00668.x. Epub 2011 Feb 9. Basic Clin Pharmacol Toxicol. 2011. PMID: 21205224
Autometallographic silver enhancement showed silver uptake in lysosomes of glia cells and neurons in the ipsilateral cortex and hippocampus alongside a minor uptake on the contralateral side. ...We conclude that metallic silver implants release silver ions causing neuroinf …
Autometallographic silver enhancement showed silver uptake in lysosomes of glia cells and neurons in the ipsilateral cortex and hippocampus …
Metallic gold beads in hyaluronic acid: a novel form of gold-based immunosuppression? Investigations of the immunosuppressive effects of metallic gold on cultured J774 macrophages and on neuronal gene expression in experimental autoimmune encephalomyelitis.
Pedersen DS, Tran TP, Smidt K, Bibby BM, Rungby J, Larsen A. Pedersen DS, et al. Biometals. 2013 Jun;26(3):369-85. doi: 10.1007/s10534-013-9616-4. Epub 2013 May 8. Biometals. 2013. PMID: 23653168
Gene expression in the macrophages showed a statistically significant decrease in Il-6, Il-1β and Il-10-response to LPS; interestingly HA induced a statistically significant increase of Il-10. ...Omnibus testing for reduced inflammatory response following gold-treat …
Gene expression in the macrophages showed a statistically significant decrease in Il-6, Il-1β and Il-10-response to LPS; interestingl …
Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells.
Nygaard SB, Larsen A, Knuhtsen A, Rungby J, Smidt K. Nygaard SB, et al. BMC Res Notes. 2014 Feb 7;7:84. doi: 10.1186/1756-0500-7-84. BMC Res Notes. 2014. PMID: 24502363 Free PMC article.
Our results suggest that regulation of zinc homeostasis could represent a pharmacological target....
Our results suggest that regulation of zinc homeostasis could represent a pharmacological target....
Exogenous metallothionein potentiates the insulin response at normal glucose concentrations in INS-1E beta-cells without disturbing intracellular ZnT8 expression.
Nygaard SB, Lund NS, Larsen A, Pedersen N, Rungby J, Smidt K. Nygaard SB, et al. Basic Clin Pharmacol Toxicol. 2015 Feb;116(2):173-7. doi: 10.1111/bcpt.12287. Epub 2014 Aug 28. Basic Clin Pharmacol Toxicol. 2015. PMID: 24964825 No abstract available.
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