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HIV-1 integrase multimerization as a therapeutic target.
Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M. Feng L, et al. Among authors: larue rc. Curr Top Microbiol Immunol. 2015;389:93-119. doi: 10.1007/82_2015_439. Curr Top Microbiol Immunol. 2015. PMID: 25778682 Free PMC article. Review.
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Larue R, et al. J Biol Chem. 2012 Oct 5;287(41):34044-58. doi: 10.1074/jbc.M112.384669. Epub 2012 Aug 7. J Biol Chem. 2012. PMID: 22872640 Free PMC article.
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: larue rc. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
BET proteins promote efficient murine leukemia virus integration at transcription start sites.
Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. Sharma A, et al. Among authors: larue rc. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41. doi: 10.1073/pnas.1307157110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818621 Free PMC article.
Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.
Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ. Aiyer S, et al. Among authors: larue rc. Nucleic Acids Res. 2014 May;42(9):5917-28. doi: 10.1093/nar/gku175. Epub 2014 Mar 12. Nucleic Acids Res. 2014. PMID: 24623816 Free PMC article.
Molecular mechanisms of retroviral integration site selection.
Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Kvaratskhelia M, et al. Among authors: larue rc. Nucleic Acids Res. 2014;42(16):10209-25. doi: 10.1093/nar/gku769. Epub 2014 Aug 21. Nucleic Acids Res. 2014. PMID: 25147212 Free PMC article.
The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. Slaughter A, et al. Among authors: larue rc. Retrovirology. 2014 Nov 25;11:100. doi: 10.1186/s12977-014-0100-1. Retrovirology. 2014. PMID: 25421939 Free PMC article.
30 results