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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease.
Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. Mahul-Mellier AL, et al. Among authors: lashuel ha. Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9. Hum Mol Genet. 2014. PMID: 24412932 Free PMC article.
Phosphorylation of synucleins by members of the Polo-like kinase family.
Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA. Mbefo MK, et al. Among authors: lashuel ha. J Biol Chem. 2010 Jan 22;285(4):2807-22. doi: 10.1074/jbc.M109.081950. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889641 Free PMC article.
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA. Paleologou KE, et al. Among authors: lashuel ha. J Neurosci. 2010 Mar 3;30(9):3184-98. doi: 10.1523/JNEUROSCI.5922-09.2010. J Neurosci. 2010. PMID: 20203178 Free PMC article.
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.
Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA. Ouertatani-Sakouhi H, et al. Among authors: lashuel ha. J Biol Chem. 2010 Aug 20;285(34):26581-98. doi: 10.1074/jbc.M110.113951. Epub 2010 Jun 1. J Biol Chem. 2010. PMID: 20516071 Free PMC article.
217 results