Lashuel HA - Search Results

1

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

Ruggeri FS, Vieweg S, Cendrowska U, Longo G, Chiki A, Lashuel HA, Dietler G. Ruggeri FS, et al. Among authors: lashuel ha. Sci Rep. 2016 Aug 8;6:31155. doi: 10.1038/srep31155. Sci Rep. 2016. PMID: 27499269 Free PMC article.

2

Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones.

Hinault MP, Cuendet AF, Mattoo RU, Mensi M, Dietler G, Lashuel HA, Goloubinoff P. Hinault MP, et al. Among authors: lashuel ha. J Biol Chem. 2010 Dec 3;285(49):38173-82. doi: 10.1074/jbc.M110.127753. Epub 2010 Sep 16. J Biol Chem. 2010. PMID: 20847048 Free PMC article.

3

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method.

Adamcik J, Lara C, Usov I, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA, Hamley IW, Mezzenga R. Adamcik J, et al. Among authors: lashuel ha. Nanoscale. 2012 Aug 7;4(15):4426-9. doi: 10.1039/c2nr30768e. Epub 2012 Jun 11. Nanoscale. 2012. PMID: 22688679 Free article.

4

Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity.

Wang ZM, Lashuel HA. Wang ZM, et al. Among authors: lashuel ha. Angew Chem Int Ed Engl. 2013 Jan 7;52(2):562-7. doi: 10.1002/anie.201206561. Epub 2012 Nov 12. Angew Chem Int Ed Engl. 2013. PMID: 23148019

5

Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation.

Jeong JS, Ansaloni A, Mezzenga R, Lashuel HA, Dietler G. Jeong JS, et al. Among authors: lashuel ha. J Mol Biol. 2013 May 27;425(10):1765-81. doi: 10.1016/j.jmb.2013.02.005. Epub 2013 Feb 13. J Mol Biol. 2013. PMID: 23415897 Free article.

6

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.

Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA. Ansaloni A, et al. Among authors: lashuel ha. Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1928-33. doi: 10.1002/anie.201307510. Epub 2014 Jan 20. Angew Chem Int Ed Engl. 2014. PMID: 24446188

7

The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity.

Khalaf O, Fauvet B, Oueslati A, Dikiy I, Mahul-Mellier AL, Ruggeri FS, Mbefo MK, Vercruysse F, Dietler G, Lee SJ, Eliezer D, Lashuel HA. Khalaf O, et al. Among authors: lashuel ha. J Biol Chem. 2014 Aug 8;289(32):21856-76. doi: 10.1074/jbc.M114.553297. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936070 Free PMC article.

8

Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.

Ruggeri FS, Adamcik J, Jeong JS, Lashuel HA, Mezzenga R, Dietler G. Ruggeri FS, et al. Among authors: lashuel ha. Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2462-6. doi: 10.1002/anie.201409050. Epub 2015 Jan 14. Angew Chem Int Ed Engl. 2015. PMID: 25588987

9

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

Burai R, Ait-Bouziad N, Chiki A, Lashuel HA. Burai R, et al. Among authors: lashuel ha. J Am Chem Soc. 2015 Apr 22;137(15):5041-52. doi: 10.1021/ja5131726. Epub 2015 Apr 8. J Am Chem Soc. 2015. PMID: 25768729

10

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation.

Vieweg S, Ansaloni A, Wang ZM, Warner JB, Lashuel HA. Vieweg S, et al. Among authors: lashuel ha. J Biol Chem. 2016 Jun 3;291(23):12074-86. doi: 10.1074/jbc.M116.713982. Epub 2016 Mar 21. J Biol Chem. 2016. PMID: 27002149 Free PMC article.

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