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A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity.
Rios-Doria J, Favata M, Lasky K, Feldman P, Lo Y, Yang G, Stevens C, Wen X, Sehra S, Katiyar K, Liu K, Wynn R, Harris JJ, Ye M, Spitz S, Wang X, He C, Li YL, Yao W, Covington M, Scherle P, Koblish H. Rios-Doria J, et al. Among authors: lasky k. Front Oncol. 2020 Dec 7;10:598477. doi: 10.3389/fonc.2020.598477. eCollection 2020. Front Oncol. 2020. PMID: 33425754 Free PMC article.
Characterization of human cancer xenografts in humanized mice.
Rios-Doria J, Stevens C, Maddage C, Lasky K, Koblish HK. Rios-Doria J, et al. Among authors: lasky k. J Immunother Cancer. 2020 Mar;8(1):e000416. doi: 10.1136/jitc-2019-000416. J Immunother Cancer. 2020. PMID: 32217760 Free PMC article.
Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines.
Driscoll DL, Chakravarty A, Bowman D, Shinde V, Lasky K, Shi J, Vos T, Stringer B, Amidon B, D'Amore N, Hyer ML. Driscoll DL, et al. Among authors: lasky k. PLoS One. 2014 Nov 3;9(11):e111060. doi: 10.1371/journal.pone.0111060. eCollection 2014. PLoS One. 2014. PMID: 25365521 Free PMC article.
MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma.
Shi JQ, Lasky K, Shinde V, Stringer B, Qian MG, Liao D, Liu R, Driscoll D, Nestor MT, Amidon BS, Rao Y, Duffey MO, Manfredi MG, Vos TJ, D' Amore N, Hyer ML. Shi JQ, et al. Among authors: lasky k. Mol Cancer Ther. 2012 Sep;11(9):2045-53. doi: 10.1158/1535-7163.MCT-11-1036. Epub 2012 May 18. Mol Cancer Ther. 2012. PMID: 22609854 Free article.
Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R, Cullis C, Driscoll DL, Elder A, Forsyth N, Frazer J, Guo J, Guo L, Hyer ML, Janowick D, Kulkarni B, Lai SJ, Lasky K, Li G, Li J, Liao D, Little J, Peng B, Qian MG, Reynolds DJ, Rezaei M, Scott MP, Sells TB, Shinde V, Shi QJ, Sintchak MD, Soucy F, Sprott KT, Stroud SG, Nestor M, Visiers I, Weatherhead G, Ye Y, D'Amore N. Duffey MO, et al. Among authors: lasky k. J Med Chem. 2012 Jan 12;55(1):197-208. doi: 10.1021/jm2011172. Epub 2011 Dec 5. J Med Chem. 2012. PMID: 22070629
Psychometric deviance measured by MMPI in adoptees at high risk for schizophrenia and their adoptive controls.
Siira V, Wahlberg KE, Miettunen J, Lasky K, Pekka Tienari PT. Siira V, et al. Among authors: lasky k. J Pers Assess. 2004 Aug;83(1):14-21. doi: 10.1207/s15327752jpa8301_02. J Pers Assess. 2004. PMID: 15271592
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