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Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency virus type 1 in vitro.
Heredia A, Gilliam B, Latinovic O, Le N, Bamba D, Devico A, Melikyan GB, Gallo RC, Redfield RR. Heredia A, et al. Among authors: latinovic o. Antimicrob Agents Chemother. 2007 Jul;51(7):2489-96. doi: 10.1128/AAC.01602-06. Epub 2007 May 7. Antimicrob Agents Chemother. 2007. PMID: 17485501 Free PMC article.
A novel small-molecule inhibitor of HIV-1 entry.
Heredia A, Latinovic OS, Barbault F, de Leeuw EP. Heredia A, et al. Drug Des Devel Ther. 2015 Oct 1;9:5469-78. doi: 10.2147/DDDT.S89338. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26491257 Free PMC article.
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