Lau AY - Search Results

1

Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics.

Yao Y, Belcher J, Berger AJ, Mayer ML, Lau AY. Yao Y, et al. Structure. 2013 Oct 8;21(10):1788-99. doi: 10.1016/j.str.2013.07.011. Epub 2013 Aug 22. Structure. 2013. PMID: 23972471 Free PMC article.

2

The free energy landscapes governing conformational changes in a glutamate receptor ligand-binding domain.

Lau AY, Roux B. Lau AY, et al. Structure. 2007 Oct;15(10):1203-14. doi: 10.1016/j.str.2007.07.015. Structure. 2007. PMID: 17937910 Free PMC article.

3

The hidden energetics of ligand binding and activation in a glutamate receptor.

Lau AY, Roux B. Lau AY, et al. Nat Struct Mol Biol. 2011 Mar;18(3):283-7. doi: 10.1038/nsmb.2010. Epub 2011 Feb 13. Nat Struct Mol Biol. 2011. PMID: 21317895 Free PMC article.

4

Molecular lock regulates binding of glycine to a primitive NMDA receptor.

Yu A, Alberstein R, Thomas A, Zimmet A, Grey R, Mayer ML, Lau AY. Yu A, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6786-E6795. doi: 10.1073/pnas.1607010113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791085 Free PMC article.

5

Glutamate and Glycine Binding to the NMDA Receptor.

Yu A, Lau AY. Yu A, et al. Structure. 2018 Jul 3;26(7):1035-1043.e2. doi: 10.1016/j.str.2018.05.004. Epub 2018 Jun 7. Structure. 2018. PMID: 29887499 Free PMC article.

6

High Conformational Variability in the GluK2 Kainate Receptor Ligand-Binding Domain.

Wied TJ, Chin AC, Lau AY. Wied TJ, et al. Structure. 2019 Jan 2;27(1):189-195.e2. doi: 10.1016/j.str.2018.09.008. Epub 2018 Oct 25. Structure. 2019. PMID: 30482727 Free PMC article.

7

D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2.

Chin AC, Yovanno RA, Wied TJ, Gershman A, Lau AY. Chin AC, et al. Structure. 2020 Oct 6;28(10):1168-1178.e2. doi: 10.1016/j.str.2020.07.005. Epub 2020 Jul 30. Structure. 2020. PMID: 32735769 Free PMC article.

8

A conformational intermediate in glutamate receptor activation.

Lau AY, Salazar H, Blachowicz L, Ghisi V, Plested AJ, Roux B. Lau AY, et al. Neuron. 2013 Aug 7;79(3):492-503. doi: 10.1016/j.neuron.2013.06.003. Neuron. 2013. PMID: 23931998 Free PMC article.

9

Dynamics of the Ligand Binding Domain Layer during AMPA Receptor Activation.

Baranovic J, Chebli M, Salazar H, Carbone AL, Faelber K, Lau AY, Daumke O, Plested AJ. Baranovic J, et al. Biophys J. 2016 Feb 23;110(4):896-911. doi: 10.1016/j.bpj.2015.12.033. Biophys J. 2016. PMID: 26910426 Free PMC article.

10

Enhanced sampling of glutamate receptor ligand-binding domains.

Lau AY. Lau AY. Neurosci Lett. 2019 May 1;700:17-21. doi: 10.1016/j.neulet.2018.04.018. Epub 2018 Apr 14. Neurosci Lett. 2019. PMID: 29665428 Review.

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