Lau J - Search Results

1

Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

Runge S, Thøgersen H, Madsen K, Lau J, Rudolph R. Runge S, et al. Among authors: lau j. J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20. J Biol Chem. 2008. PMID: 18287102

2

Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues.

Conde-Frieboes K, Thøgersen H, Lau JF, Sensfuss U, Hansen TK, Christensen L, Spetzler J, Olsen HB, Nilsson C, Raun K, Dahl K, Hansen BS, Wulff BS. Conde-Frieboes K, et al. Among authors: lau jf. J Med Chem. 2012 Mar 8;55(5):1969-77. doi: 10.1021/jm201489a. Epub 2012 Feb 24. J Med Chem. 2012. PMID: 22335602

3

Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.

Lau JF, Jeppesen CB, Rimvall K, Hohlweg R. Lau JF, et al. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5303-8. doi: 10.1016/j.bmcl.2006.07.093. Bioorg Med Chem Lett. 2006. PMID: 16908150

4

Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

Andersen HS, Olsen OH, Iversen LF, Sørensen AL, Mortensen SB, Christensen MS, Branner S, Hansen TK, Lau JF, Jeppesen L, Moran EJ, Su J, Bakir F, Judge L, Shahbaz M, Collins T, Vo T, Newman MJ, Ripka WC, Møller NP. Andersen HS, et al. Among authors: lau jf. J Med Chem. 2002 Sep 26;45(20):4443-59. doi: 10.1021/jm0209026. J Med Chem. 2002. PMID: 12238924

5

Parallel solid-phase synthesis of disubstituted (5-biphenyltetrazolyl) hydantoins and thiohydantoins targeting the growth hormone secretagogue receptor.

Severinsen R, Lau JF, Bondensgaard K, Hansen BS, Begtrup M, Ankersen M. Severinsen R, et al. Bioorg Med Chem Lett. 2004 Jan 19;14(2):317-20. doi: 10.1016/j.bmcl.2003.11.012. Bioorg Med Chem Lett. 2004. PMID: 14698149

6

Long acting analogue of the calcitonin gene-related peptide induces positive metabolic effects and secretion of the glucagon-like peptide-1.

Nilsson C, Hansen TK, Rosenquist C, Hartmann B, Kodra JT, Lau JF, Clausen TR, Raun K, Sams A. Nilsson C, et al. Eur J Pharmacol. 2016 Feb 15;773:24-31. doi: 10.1016/j.ejphar.2016.01.003. Epub 2016 Jan 22. Eur J Pharmacol. 2016. PMID: 26808305

7

Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.

Lau J, Bloch P, Schäffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T. Lau J, et al. J Med Chem. 2015 Sep 24;58(18):7370-80. doi: 10.1021/acs.jmedchem.5b00726. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26308095

8

Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties.

Madsen P, Kodra JT, Behrens C, Nishimura E, Jeppesen CB, Pridal L, Andersen B, Knudsen LB, Valcarce-Aspegren C, Guldbrandt M, Christensen IT, Jørgensen AS, Ynddal L, Brand CL, Bagger MA, Lau J. Madsen P, et al. Among authors: lau j. J Med Chem. 2009 May 14;52(9):2989-3000. doi: 10.1021/jm8016249. J Med Chem. 2009. PMID: 19385613

9

Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor.

Kodra JT, Jørgensen AS, Andersen B, Behrens C, Brand CL, Christensen IT, Guldbrandt M, Jeppesen CB, Knudsen LB, Madsen P, Nishimura E, Sams C, Sidelmann UG, Pedersen RA, Lynn FC, Lau J. Kodra JT, et al. Among authors: lau j. J Med Chem. 2008 Sep 11;51(17):5387-96. doi: 10.1021/jm7015599. Epub 2008 Aug 16. J Med Chem. 2008. PMID: 18707090

10

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.

Teng M, Johnson MD, Thomas C, Kiel D, Lakis JN, Kercher T, Aytes S, Kostrowicki J, Bhumralkar D, Truesdale L, May J, Sidelman U, Kodra JT, Jørgensen AS, Olesen PH, de Jong JC, Madsen P, Behrens C, Pettersson I, Knudsen LB, Holst JJ, Lau J. Teng M, et al. Among authors: lau j. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5472-8. doi: 10.1016/j.bmcl.2007.06.086. Epub 2007 Jul 4. Bioorg Med Chem Lett. 2007. PMID: 17827014

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